Trial reportAmerican journal of physiology. Endocrinology and metabolism2018
Triiodothyronine and leptin repletion in humans similarly reverse weight-loss-induced changes in skeletal muscle.
Trial report in American journal of physiology. Endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00265980 (Leptin in Human Energy and Neuroendocrine Homeostasis), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leptin in Human Energy and Neuroendocrine Homeostasis
Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens.International journal of obesity (2005) · 2026Article
- Effects of Glucagon-Like Peptide-1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Article
- Metabolic and appetitive regulation of adipocyte mass during treatment of obesity.Journal of internal medicine · 2026Review
- Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity.Reviews in endocrine & metabolic disorders · 2025Review
- Article
- The relationship between cardiorespiratory fitness and indices of fat mass and fat-free mass in adults.Frontiers in sports and active living · 2025Article
- Weight History Correlates of Resting Energy Expenditure in Women With Bulimia Nervosa.The International journal of eating disorders · 2024Article
- Does eating less or exercising more to reduce energy availability produce distinct metabolic responses?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Differential mechanisms affecting weight loss and weight loss maintenance.Nature metabolism · 2023Review
- Alterations in skeletal muscle morphology and mechanics in juvenile male Sprague Dawley rats exposed to a high-fat high-sucrose diet.Scientific reports · 2023Article
- Leptin Increases: Physiological Roles in the Control of Sympathetic Nerve Activity, Energy Balance, and the Hypothalamic-Pituitary-Thyroid Axis.International journal of molecular sciences · 2023Review
- Tissue losses and metabolic adaptations both contribute to the reduction in resting metabolic rate following weight loss.International journal of obesity (2005) · 2022Article
- Physiology of the Weight-Reduced State: A Report from a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.Obesity (Silver Spring, Md.) · 2021Article
- Reduced metabolic efficiency in sedentary eucaloric conditions predicts greater weight regain in adults with obesity following sustained weight loss.International journal of obesity (2005) · 2021Article
- Describing the Weight-Reduced State: Physiology, Behavior, and Interventions.Obesity (Silver Spring, Md.) · 2021Article
- Strategies to Understand the Weight-Reduced State: Genetics and Brain Imaging.Obesity (Silver Spring, Md.) · 2021Review
- The Role of Leptin in the Development of Energy Homeostatic Systems and the Maintenance of Body Weight.Frontiers in physiology · 2021Review
- Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure.The Journal of biological chemistry · 2020Article
- Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism.Thyroid : official journal of the American Thyroid Association · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Subjects maintaining a ≥10% dietary weight loss exhibit decreased circulating concentrations of bioactive thyroid hormones and increased skeletal muscle work efficiency largely due to increased expression of more-efficient myosin heavy chain (MHC) isoforms (MHC I) and significantly mediated by the adipocyte-derived hormone leptin. The primary purpose of this study was to examine the effects of triiodothyronine (T
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.