Evidence map›Paper›PMID 29917243›Full record

ArticleThe Journal of physiology2018

Sex-specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles.

Mu Chen, Dechun Yin, Shuai Guo, Dong-Zhu Xu, Zhuo Wang, Zhenhui Chen, Michael Rubart-von der Lohe, Shien-Fong Lin, Thomas H Everett Iv, James N Weiss and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Small-conductance CaThe Journal of physiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Activation of Small Conductance CaInternational journal of molecular sciences · 2025
    Article
  7. Primary Electrical Heart Disease-Principles of Pathophysiology and Genetics.International journal of molecular sciences · 2024
    Review
  8. Dual effects of the small-conductance CaAmerican journal of physiology. Heart and circulatory physiology · 2023
    Article
  9. Activation of small conductance CaThe Journal of physiology · 2023
    Article
  10. Small conductance calcium activated KInternational journal of cardiology. Heart & vasculature · 2021
    Article
  11. Review
  12. Review
  13. Sex-specific IHeart rhythm · 2021
    Article
  14. Article
  15. Impact of IBiophysical journal · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Mu ChenKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Dechun YinKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Shuai GuoKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Dong-Zhu XuKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Zhuo WangKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Zhenhui ChenKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Michael Rubart-von der LoheDepartment of Pediatrics, Riley Heart Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Shien-Fong LinKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Thomas H Everett IvKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-4235-3838
James N WeissDepartments of Medicine (Cardiology) and Physiology, University of California, Los Angeles, CA, USA.
Peng-Sheng ChenKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-4150-5836
Indiana University School of MedicineHarbin Medical University · CNNational Yang Ming Chiao Tung University · TWShanghai Jiao Tong University · CNUniversity of California, Los Angeles · USUniversity of Tsukuba · JPWuhan University · CN

Funding

WAVE DYNAMICS IN NORMAL AND DISEASED RABBIT HEARTSP01HL078931 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, JAMES · 2005 to 2015
$20.7M
Skin Sympathetic Nerve Activity and Cardiac ArrhythmiasR42DA043391 · NIDA · ARRHYTHMOTECH, LLC · PI EVERETT, THOMAS H · 2016 to 2017
$1.5M
Neuromodulation for Atrial Fibrillation ControlR56HL071140 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CHEN, PENG-SHENG · 2016 to 2016
$461k
Charles Fisch Cardiovascular Research Award, Krannert Institute of Cardiology 29-827-11 MCHENHHS, NIH, National Heart, Lung, and Blood Institute P01HL78931HHS, NIH, National Heart, Lung, and Blood Institute R56HL71140HHS, NIH, NIDA R42DA043391NHLBI NIH HHS P01 HL078931NHLBI NIH HHS R56 HL071140NIDA NIH HHS R42 DA043391NIH/SPARC TR0022080
6 · The paper itself

Abstract

key pointsIt is unknown if a sex difference exists in cardiac apamin-sensitive small conductance Ca ABSTRACT: Sex has a large influence on cardiac electrophysiological properties. Whether sex differences exist in apamin-sensitive small conductance Ca

Indexed as

Action PotentialsHeart RateAdrenergic beta-AgonistsAnimalsApaminCells, CulturedFemaleHeart VentriclesIsoproterenolMaleMyocytes, CardiacRabbitsSex FactorsSmall-Conductance Calcium-Activated Potassium ChannelsAdrenergic beta-AgonistsApaminIsoproterenolSmall-Conductance Calcium-Activated Potassium ChannelsCa2+ activated potassium channelsex dimorphismventricular arrhythmias

Identifiers

PMID29917243
PMCPMC6138290
OpenAlexW2888762420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.