Evidence map›Paper›PMID 29917234›Full record

ArticleThe Journal of physiology2018

Modulation of ClC-3 gating and proton/anion exchange by internal and external protons and the anion selectivity filter.

Jeffrey Rohrbough, Hong-Ngan Nguyen, Fred S Lamb

Abstract read
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  6. Review
  7. Article
  8. Review
  9. Functional Characterization ofFrontiers in molecular neuroscience · 2022
    Article
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  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
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  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jeffrey RohrboughDepartments of Pediatrics and Molecular Physiology & Biophysics, Monroe Carell Children's Hospital at Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-6742-4543
Hong-Ngan NguyenDepartments of Pediatrics and Molecular Physiology & Biophysics, Monroe Carell Children's Hospital at Vanderbilt University, Nashville, TN, USA.
Fred S LambDepartments of Pediatrics and Molecular Physiology & Biophysics, Monroe Carell Children's Hospital at Vanderbilt University, Nashville, TN, USA.ORCID 0000-0003-2955-5133

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Ductus Arteriosus Regulation by Anion ChannelsR01HL128386 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LAMB, FRED S, REESE, JOHN JEFFREY · 2016 to 2019
$2.3M
LSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560k
NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NHLBI NIH HHS R01 HL128386NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIH HHS S10 OD021630
6 · The paper itself

Abstract

key pointsThe ClC-3 2Cl ABSTRACT: We utilized plasma membrane-localized ClC-3 to investigate relationships between steady-state transport current (I

Indexed as

ProtonsAnionsCell MembraneChloride ChannelsGlutamic AcidHEK293 CellsHumansHydrogen-Ion ConcentrationIon Channel GatingIon TransportKineticsMutationTyrosineAnionsChloride ChannelsClC-3 channelCLC-5 chloride channelGlutamic AcidProtonsTyrosinechloride-proton exchangeClC-3gating currentpH dependenceproton transport

Identifiers

PMID29917234
PMCPMC6117567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.