Evidence map›Paper›PMID 29917119›Full record

ArticleJournal of the National Cancer Institute2019

Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Stephanie L Schmit, Christopher K Edlund, Fredrick R Schumacher, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Chenxu Qu, Marilena Melas, David J Van Den Berg, Hansong Wang and 173 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 121 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328677 recruitingnot on this map

ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis

TypeobservationalSponsorUniversity of UtahRan2007 to 2030Enrolled5,000ConditionsColorectal Cancer
NCT04331535 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care

TypeinterventionalSponsorBoston VA Research Institute, Inc.Ran2020 to 2025Enrolled1,076ConditionsCoronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal CancerArmsPolygenic risk score (PRS)
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Guideline
  2. Pooled it
  3. Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Genetic Variant Associated With Survival of Patients With Stage II-III Colon Cancer.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2020
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Article
  11. Article
  12. Article
  13. Polygenic risk scores in cancer.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
    Article
  14. Article
  15. Article
  16. Article
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  20. The Translational Research Program in Cancer Differences across Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

183 authors.

Stephanie L SchmitDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Christopher K EdlundDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Fredrick R SchumacherDepartment of Epidemiology and Biostatistics.
Jian GongPublic Health Sciences Division.
Tabitha A HarrisonPublic Health Sciences Division.
Jeroen R HuyghePublic Health Sciences Division.
Chenxu QuDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Marilena MelasDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
David J Van Den BergDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Hansong WangEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.
Stephanie TringDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Sarah J PlummerCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
M Henar AlonsoCatalan Institute of Oncology, Bellvitge Biomedical Research Institute.
Christopher I AmosDepartment of Biomedical Data Science.
Kristen AntonDepartment of Biomedical Data Science.
Aaron K AragakiPublic Health Sciences Division.
Volker ArndtDivision of Clinical Epidemiology and Aging Research.
Elizabeth L BarryDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Stéphane BezieauPublic Health Sciences Division.
Stephanie BienCentre Hospitalier Universitaire Hotel-Dieu, Nantes, France.
Amanda BloomerDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Juergen BoehmHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT.
Marie-Christine Boutron-RuaultCESP (U1018 INSERM), Facultés de Médecine Université Paris-Sud, UVSQ, Université Paris-Saclay, Villejuif, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research.
Stefanie BrezinaService de Génétique Médicale, Centre Hospitalier Universitaire (CHU), Nantes, France.
Daniel D BuchananCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Katja ButterbachDivision of Clinical Epidemiology and Aging Research.
Bette J CaanDivision of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, CA.
Peter T CampbellEpidemiology Research Program, American Cancer Society, Atlanta, GA.
Christopher S CarlsonPublic Health Sciences Division.
Jose E CastelaoGenetic Oncology Unit, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Complejo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo (Pontevedra) Spain.
Andrew T ChanDivision of Gastroenterology.
Jenny Chang-ClaudeUnit of Genetic Epidemiology, Division of Cancer Epidemiology.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Iona ChengCancer Prevention Institute of California, Fremont, CA.
Ya-Wen ChengPh.D. Program of Cancer Research and Drug Discovery.
Lee Soo ChinCancer Science Institute of Singapore, National University of Singapore, Singapore.
James M ChurchDepartment of Colorectal Surgery, Cleveland Clinic, Cleveland, OH.
Timothy ChurchDivision of Environmental Health Sciences, University of Minnesota, Minneapolis, MN.
Gerhard A CoetzeeVan Andel Research Institute, Grand Rapids, MI.
Michelle CotterchioPrevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada.
Marcia Cruz CorreaPuerto Rico Cancer Center.
Keith R CurtisPublic Health Sciences Division.
David DugganGenetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, AZ.
Douglas F EastonCentre for Cancer Genetic Epidemiology.
Dallas EnglishCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Edith J M FeskensDivision of Human Nutrition, Wageningen University and Research, Wageningen, the Netherlands.
Rocky FischerUniversity of Michigan Comprehensive Cancer Center, Ann Arbor, MI.
Liesel M FitzGeraldCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Barbara K FortiniW.M. Keck Science Department, Claremont Colleges, Claremont, CA.
Lars G FritscheDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI.
Charles S FuchsDepartment of Medical Oncology, Dana-Farber Cancer Institute, Brookline, MA.
Manuela Gago-DominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago De Compostela, Spain.
Manish GalaDivision of Gastroenterology.
Steven J GallingerZane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
W James GaudermanDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Edward L GiovannucciHarvard Medical School, Boston, MA.
Stephanie M GogartenDepartment of Biostatistics.
Clicerio Gonzalez-VillalpandoUnidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico.
Elena M Gonzalez-VillalpandoCentro de Estudios en Diabetes AC, Mexico City, Mexico.
William M GradyDepartment of Medicine, Division of Gastroenterology, School of Medicine.
Joel K GreensonDepartment of Pathology, University of Michigan, Ann Arbor, MI.
Andrea GsurMedical University of Vienna, Department of Medicine I, Institute of Cancer Research, Vienna, Austria.
Marc GunterClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.
Christopher A HaimanDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Jochen HampeMedical Department 1, University Hospital Dresden, TU Dresden, Dresden, Germany.
Sophia HarlidDepartment of Radiation Sciences, Oncology, Umea University, Umea, Sweden.
John F HarjuUniversity of Michigan Comprehensive Cancer Center, Ann Arbor, MI.
Richard B HayesDivision of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY.
Philipp HoferMedical University of Vienna, Department of Medicine I, Institute of Cancer Research, Vienna, Austria.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research.
John L HopperCentre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria, Australia.
Shu-Chen HuangDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Jose Maria HuertaDepartment of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
Thomas J HudsonAbbVie, Redwood City, CA.
David J HunterProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA.
Gregory E IdosDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Motoki IwasakiDivision of Epidemiology, Center for Public Health Sciences.
Rebecca D JacksonDepartment of Medicine, Ohio State University, Columbus, OH.
Eric J JacobsEpidemiology Research Program, American Cancer Society, Atlanta, GA.
Sun Ha JeeDepartment of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea.
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Wei-Hua JiaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yatsen University, Guangzhou, China.
Shuo JiaoPublic Health Sciences Division.
Amit D JoshiClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.
Laurence N KolonelOffice of Public Health Studies, University of Hawaii Manoa, Honolulu, HI.
Suminori KonoService de Génétique Médicale, Centre Hospitalier Universitaire (CHU), Nantes, France.
Charles KooperbergPublic Health Sciences Division.
Vittorio KroghEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Tilman KuehnDivision of Cancer Epidemiology.
Sébastien KüryDepartment of Preventive Medicine, Kyushu University, Fukuoka, Japan.
Andrea LaCroixPublic Health Sciences Division.
Cecelia A LaurieDepartment of Biostatistics.
Flavio LejbkowiczDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Mathieu LemireOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Heinz-Josef LenzDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
David LevineDepartment of Biostatistics.
Christopher I LiTranslational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA.
Li LiDepartment of Family Medicine and Community Health, Mary Ann Swetland Center for Environmental Health, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH.
Wolfgang LiebInstitute of Epidemiology, PopGen Biobank, Christian-Albrechts-University Kiel, Kiel, Germany.
Yi LinPublic Health Sciences Division.
Noralane M LindorDepartment of Health Science Research, Mayo Clinic, Scottsdale, AZ.
Yun-Ru LiuJoint Biobank, Office of Human Research.
Fotios LoupakisPh.D. Program of Cancer Research and Drug Discovery.
Yingchang LuDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN.
Frank LuhClalit Health Services National Israeli Cancer Control Center, Haifa, Israel.
Jing MaHarvard School of Public Health, Boston, MA.
Christoph MancaoGenentech, Inc., Basel, Switzerland.
Frank J ManionUniversity of Michigan Comprehensive Cancer Center, Ann Arbor, MI.
Sanford D MarkowitzDepartments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, OH.
Vicente MartinBiomedicine Institute (IBIOMED), University of León, León, Spain.
Koichi MatsudaVanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN.
Keitaro MatsuoDepartment of Epidemiology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.
Kevin J McDonnellDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Caroline E McNeilDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Roger MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Antonio J MolinaCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Bhramar MukherjeeUniversity of Michigan Comprehensive Cancer Center, Ann Arbor, MI.
Neil MurphyNutrition and Metabolism Section, IARC, Lyon, CEDEX 08, France.
Polly A NewcombPublic Health Sciences Division.
Kenneth OffitClinical Genetics Service (KO), Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Hanane OmichessanCESP (U1018 INSERM), Facultés de Médecine Université Paris-Sud, UVSQ, Université Paris-Saclay, Villejuif, France.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
Jesus P Paredes CotoréDepartment of Surgery, Complejo Hospitalario Universitario de Santiago (CHUS), Servicio Galego de Saúde (SERGAS), Santiago De Compostela, Spain.
Julyann Pérez-MayoralDivision of Cancer Biology, University of Puerto Rico, San Juan, Puerto Rico.
Paul D PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
John D PotterPublic Health Sciences Division.
Conghui QuDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Leon RaskinDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN.
Gad RennertClalit Health Services National Israeli Cancer Control Center, Haifa, Israel.
Hedy S RennertClalit Health Services National Israeli Cancer Control Center, Haifa, Israel.
Bridget M RiggsDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Clemens SchafmayerDepartment of Visceral and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel Campus, Kiel, Germany.
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA.
Thomas A SellersDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Daniela SeminaraEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Gianluca SeveriCESP (U1018 INSERM), Facultés de Médecine Université Paris-Sud, UVSQ, Université Paris-Saclay, Villejuif, France.
Wei ShiDepartment of Surgery, Children's Hospital Los Angeles, Los Angeles, CA.
David ShibataDepartment of Surgery, University of Tennessee Health Science Center, Memphis, TN.
Xiao-Ou ShuDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN.
Erin M SiegelDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Martha L SlatteryDepartment of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT.
Melissa SoutheyColorectal Oncogenomics Group, Department of Pathology (DDB) and Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
Zsofia K StadlerClinical Genetics Service (KO), Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Mariana C SternDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Sebastian StintzingDepartment of Hematology and Oncology University of Munich (LMU), Munich, Germany.
Darin TavernaPhoenix College, Phoenix, AZ.
Stephen N ThibodeauMayo Clinic, Rochester, MN.
Duncan C ThomasDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Shoichiro TsuganeDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT.
Franzel J B van DuijnhovenDivision of Human Nutrition, Wageningen University and Research, Wageningen, the Netherlands.
Bethany van Guelpan
Joseph VijaiClinical Genetics Service (KO), Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Jarmo VirtamoDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Emily WhitePublic Health Sciences Division.
Aung Ko WinCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Alicja WolkInstitute of Environmental Medicine.
Michael WoodsDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Anna H WuDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Kana WuDepartment of Nutrition, Harvard School of Public Health, Boston, MA.
Yong-Bing XiangState Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Yun YenPh.D. Program of Cancer Research and Drug Discovery.
Brent W ZankeClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Yi-Xin ZengState Key Laboratory of Oncology in South China, Cancer Center, Sun Yatsen University, Guangzhou, China.
Ben ZhangDivision of Noncommunicable Disease Epidemiology and Southwest Hospital Clinical Research Center, Third Military Medical University, Chongqing, China.
Niha ZubairPublic Health Sciences Division.
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Jane C FigueiredoDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Wei ZhengDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet Solna, Stockholm, Sweden.
Victor MorenoCatalan Institute of Oncology, Bellvitge Biomedical Research Institute.
Ulrike PetersDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.
Li HsuPublic Health Sciences Division.
David V ContiDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.
Stephen B GruberDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Tissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI EL-BARDEESY, NABEEL, SELLERS, WILLIAM R · 2007 to 2023
$33.2M
PLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5M
Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 16561CCR NIH HHS HHSN261200800001CCCR NIH HHS HHSN261201300011CCCR NIH HHS N01 RC037004Intramural NIH HHS Z01 CP010200NCI NIH HHS HHSN261200800001ENCI NIH HHS HHSN261201000006CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000121CNCI NIH HHS HHSN261201300012INCI NIH HHS HHSN261201300021CNCI NIH HHS K05 CA154337NCI NIH HHS N01 CN045165NCI NIH HHS N01 CN067009NCI NIH HHS N01 PC035137NCI NIH HHS N01 PC035142NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA196569NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA060987NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA104132NCI NIH HHS R01 CA126895NCI NIH HHS R01 CA132839NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA140561NCI NIH HHS R01 CA144040NCI NIH HHS R01 CA148667NCI NIH HHS R01 CA155101NCI NIH HHS R01 CA188214NCI NIH HHS R01 CA189184NCI NIH HHS R01 CA195789NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA207371NCI NIH HHS R37 CA054281NCI NIH HHS R37 CA070867NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA152756NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA181770NCI NIH HHS U01 CA196386NCI NIH HHS U01 CA206110NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA182910NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004726NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIDA NIH HHS R01 DA006227NIDA NIH HHS R01 DA033684NIDDK NIH HHS K01 DK110267NIDDK NIH HHS P30 DK058404NIEHS NIH HHS T32 ES013678NIGMS NIH HHS P20 GM103534NIH HHS S10 OD020069NIMH NIH HHS R01 MH090936NIMH NIH HHS R01 MH090937NIMH NIH HHS R01 MH090941NIMH NIH HHS R01 MH090948NIMH NIH HHS R01 MH090951NIMH NIH HHS R01 MH101782NIMH NIH HHS R01 MH101810NIMH NIH HHS R01 MH101814NIMH NIH HHS R01 MH101819NIMH NIH HHS R01 MH101820NIMH NIH HHS R01 MH101822NIMH NIH HHS R01 MH101825World Health Organization 001
6 · The paper itself

Abstract

backgroundPrevious genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk.

methodsWe conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315). In the discovery stage (36 948 case subjects/30 864 control subjects), we identified genetic variants with a minor allele frequency of 1% or greater associated with risk of CRC using logistic regression followed by a fixed-effects inverse variance weighted meta-analysis. All novel independent variants reaching genome-wide statistical significance (two-sided P < 5 × 10-8) were tested for replication in separate European ancestry samples (12 952 case subjects/48 383 control subjects). Next, we examined the generalizability of discovered variants in East Asians, African Americans, and Hispanics (12 085 case subjects/22 083 control subjects). Finally, we examined the contributions of novel risk variants to familial relative risk and examined the prediction capabilities of a polygenic risk score. All statistical tests were two-sided.

resultsThe discovery GWAS identified 11 variants associated with CRC at P < 5 × 10-8, of which nine (at 4q22.2/5p15.33/5p13.1/6p21.31/6p12.1/10q11.23/12q24.21/16q24.1/20q13.13) independently replicated at a P value of less than .05. Multiethnic follow-up supported the generalizability of discovery findings. These results demonstrated a 14.7% increase in familial relative risk explained by common risk alleles from 10.3% (95% confidence interval [CI] = 7.9% to 13.7%; known variants) to 11.9% (95% CI = 9.2% to 15.5%; known and novel variants). A polygenic risk score identified 4.3% of the population at an odds ratio for developing CRC of at least 2.0.

conclusionsThis study provides insight into the architecture of common genetic variation contributing to CRC etiology and improves risk prediction for individualized screening.

Indexed as

Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideCase-Control StudiesColorectal NeoplasmsEthnicityFollow-Up StudiesGenotypeHumansPrognosisUnited States

Identifiers

PMID29917119
PMCPMC6555904

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