ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Cross-Sectional Association of Frailty and Arterial Stiffness in Community-Dwelling Older Adults: The Framingham Heart Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Frailty measurement, prevalence, incidence, and clinical implications in people with diabetes: a systematic review and study-level meta-analysis.The lancet. Healthy longevity · 2020Pooled it
- Trial
- Protein-Added Healthy Lunch-Boxes Combined with Exercise for Improving Physical Fitness and Vascular Function in Pre-Frail Older Women: A Community-Based Randomized Controlled Trial.Clinical interventions in aging · 2023Trial
- Effect of Vitamin D3 and Omega-3 Fatty Acid Supplementation on Risk of Frailty: An Ancillary Study of a Randomized Clinical Trial.JAMA network open · 2022Trial
- The predictive value of the hospital frailty risk score for 28-day mortality in older critically ill patients with acute ischemic stroke.BMC geriatrics · 2026Article
- Review
- Characterizing the Clinical, Vascular, and Functional Phenotype of Metabolic Acidosis in Kidney Transplantation: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- The Biological Mechanisms of Frailty: Focusing on Cellular Senescence.European cardiology · 2026Review
- Association between health-related physical fitness and incident hypertension among the elderly in Wuhan: a seven-year cohort study.BMC public health · 2025Article
- What Do We Know About Prevention of Frailty in Women?American journal of lifestyle medicine · 2025Review
- First-Line β-Blocker Use for Hypertension in the Veterans Health Administration.JAMA network open · 2025Article
- Office and home blood pressure and their difference according to frailty status among community-dwelling older adults: the NOSE study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Association between salt intake and blood pressure among community-dwelling older adults based on their physical frailty status.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Trends in Initial Antihypertensive Medication Prescribing Among >2.8 Million Veterans Newly Diagnosed With Hypertension, 2000 to 2019.Journal of the American Heart Association · 2024Article
- Measuring Frailty Using Self-Report or Automated Tools to Identify Risk of Cardiovascular Events and Mortality: The Million Veteran Program.Journal of the American Heart Association · 2024Article
- Endothelial Dysfunction as a Key Link between Cardiovascular Disease and Frailty: A Systematic Review.Journal of clinical medicine · 2024Review
- Interaction between hypertension and frailty and their impact on death risk in older adults: a follow-up study.BMC geriatrics · 2024Article
- Correlates of Frailty in Hospitalized Older Adults with Hypertension and Its Influence on Clinical Prognosis.International journal of general medicine · 2024Article
- Association of estimated carotid-femoral pulse wave velocity with frailty in middle-aged and older adults with cardiometabolic disease.Aging clinical and experimental research · 2023Article
- Comparison of Claims-Based Frailty Indices in U.S. Veterans 65 and Older for Prediction of Long-Term Institutionalization and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundFrailty is a risk factor for cardiovascular disease (CVD). Underlying mechanisms to explain the connection between frailty and CVD are unclear. We sought to examine the association between frailty and arterial stiffness, a precursor of hypertension and CVD.
methodsWe conducted a cross-sectional analysis of community-dwelling Framingham Heart Study Offspring and Omni participants ≥60 years of age examined in 2005-2008. Frailty was defined primarily according to the Fried physical phenotype definition, which identifies nonfrail, prefrail, and frail individuals. Arterial stiffness was assessed using carotid-femoral pulse wave velocity (CFPWV). Generalized linear regression was used to examine the association between frailty level and CFPWV (modeled as -1000/CFPWV in msec/m, then transformed back to the original scale, m/s), adjusted for age, sex, cohort, mean arterial pressure, heart rate, height, and smoking.
resultsOf 2,171 participants (55% women, 91% white), 45% were prefrail and 7% were frail. Mean ages were 67, 70, and 73 years, and adjusted CFPWV least squares means were 10.0 (95% CI, 9.9-10.1), 10.3 (10.2-10.5), and 10.5 m/s (10.1-11.0); p = .0002 for nonfrail, prefrail, and frail groups, respectively. Results were similar using the Rockwood cumulative deficit model of frailty, and in a sensitivity analysis adjusting for prevalent coronary heart disease and diabetes.
conclusionsPrefrailty and frailty were associated with higher arterial stiffness in a cohort of community-dwelling older adults. Arterial stiffness may help explain the relationship between frailty and CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.