ArticleThe Analyst2018
SABRE hyperpolarization enables high-sensitivity
Article in The Analyst, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Enabling Quantitative BenchtopMagnetic resonance in chemistry : MRC · 2026Article
- Mixture Analysis at Micromolar Concentrations with 2D Benchtop NMR Enhanced by SABRE Hyperpolarization.Analytical chemistry · 2026Article
- AutomatedAnalytical chemistry · 2026Article
- Benchtop NMR signal enhancement of metabolites in urine extract using SABRE.Chemical communications (Cambridge, England) · 2026Article
- A Controlled System for Parahydrogen Hyperpolarization Experiments.Molecules (Basel, Switzerland) · 2025Article
- Quantitative Nuclear Magnetic Resonance Spectroscopy with Overhauser Dynamic Nuclear Polarization.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Quantitative Trace Analysis of Dilute Mixtures Using a Benchtop NMR System with SABRE Hyperpolarization.Analytical chemistry · 2025Article
- Overhauser Dynamic Nuclear Polarization Enables Single Scan BenchtopAnalytical chemistry · 2025Article
- Development of a fully automated workstation for conducting routine SABRE hyperpolarization.Scientific reports · 2024Article
- Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation.Nature communications · 2023Article
- EnhancingACS measurement science au · 2023Article
- SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents.International journal of molecular sciences · 2023Article
- Glycolytic Plasticity of Metastatic Lung Cancer Captured by NoninvasiveMetabolites · 2023Article
- Recent advances in the application of parahydrogen in catalysis and biochemistry.RSC advances · 2022Review
- Parahydrogen-Induced Polarization of Amino Acids.Angewandte Chemie (International ed. in English) · 2021Review
- Low-cost low-field NMR and MRI: Instrumentation and applications.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Continuous Radio Amplification by Stimulated Emission of Radiation using Parahydrogen Induced Polarization (PHIP-RASER) at 14 Tesla.Chemphyschem : a European journal of chemical physics and physical chemistry · 2020Article
- Acquisition strategies for spatially resolved magnetic resonance detection of hyperpolarized nuclei.Magma (New York, N.Y.) · 2020Review
- Automated pneumatic shuttle for magnetic field cycling and parahydrogen hyperpolarized multidimensional NMR.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- RapidChemical science · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Benchtop NMR spectrometers operating with low magnetic fields of 1-2 T at sub-ppm resolution show great promise as analytical platforms that can be used outside the traditional laboratory environment for industrial process monitoring. One current limitation that reduces the uptake of benchtop NMR is associated with the detection fields' reduced sensitivity. Here we demonstrate how para-hydrogen (p-H2) based signal amplification by reversible exchange (SABRE), a simple to achieve hyperpolarization technique, enhances agent detectability within the environment of a benchtop (1 T) NMR spectrometer so that informative 1H and 13C NMR spectra can be readily recorded for low-concentration analytes. SABRE-derived 1H NMR signal enhancements of up to 17 000-fold, corresponding to 1H polarization levels of P = 5.9%, were achieved for 26 mM pyridine in d4-methanol in a matter of seconds. Comparable enhancement levels can be achieved in both deuterated and protio solvents but now the SABRE-enhanced analyte signals dominate due to the comparatively weak thermally-polarized solvent response. The SABRE approach also enables the acquisition of 13C NMR spectra of analytes at natural isotopic abundance in a single scan as evidenced by hyperpolarized 13C NMR spectra of tens of millimolar concentrations of 4-methylpyridine. Now the associated signal enhancement factors are up to 45 500 fold (P = 4.0%) and achieved in just 15 s. Integration of an automated SABRE polarization system with the benchtop NMR spectrometer framework produces renewable and reproducible NMR signal enhancements that can be exploited for the collection of multi-dimensional NMR spectra, exemplified here by a SABRE-enhanced 2D COSY NMR spectrum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.