Evidence map›Paper›PMID 29916733›Full record

ArticleArtificial cells, nanomedicine, and biotechnology2018

Increasing the stability of Lumbricus terrestris erythrocruorin via poly(acrylic acid) conjugation.

Kyle Spivack, Matthew Tucker, Devon Zimmerman, Matthew Nicholas, Osheiza Abdulmalik, Noelle Comolli, Jacob Elmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial cells, nanomedicine, and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Optimizing the lyophilization ofArtificial cells, nanomedicine, and biotechnology · 2024
    Article
  2. Review
  3. Purification ofACS biomaterials science & engineering · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kyle Spivacka Department of Chemical Engineering , Villanova University , Villanova , PA , USA.
Matthew Tuckera Department of Chemical Engineering , Villanova University , Villanova , PA , USA.
Devon Zimmermana Department of Chemical Engineering , Villanova University , Villanova , PA , USA.
Matthew Nicholasa Department of Chemical Engineering , Villanova University , Villanova , PA , USA.
Osheiza Abdulmalikb Division of Hematology , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.
Noelle Comollia Department of Chemical Engineering , Villanova University , Villanova , PA , USA.
Jacob Elmera Department of Chemical Engineering , Villanova University , Villanova , PA , USA.ORCID http://orcid.org/0000-0001-6980-489X

Funding

Evaluation of Invertebrate Hemoglobins as Effective, Safe, and Ultra-Stable Blood SubstitutesR15HL133880 · NHLBI · VILLANOVA UNIVERSITY · PI ELMER, JACOB JAMES · 2017 to 2017
$432k
NHLBI NIH HHS R15 HL133880
6 · The paper itself

Abstract

Since donated red blood cells must be constantly refrigerated, they are often unavailable in remote areas and battlefields. The goal of this study was to synthesize a highly stable blood substitute that does not require refrigeration. Specifically, the extracellular haemoglobin (a.k.a. erythrocruorin, Ec) of the earthworm Lumbricus terrestris erythrocruororin (LtEc) was cross-linked with poly(acrylic acid) (PAA) and ethylene diamine (EDA). PAGE analysis of the LtEc nanoparticles reveals cross-linking between subunits, while dynamic light scattering and scanning electron microscopy show that cross-linking significantly increases the size of the LtEc nanoparticles (164 ± 13.9 nm). Cross-linking also significantly increased the thermal stability of the LtEc nanoparticles by 10 °C (T

Indexed as

OligochaetaAcrylic ResinsAnimalsErythrocruorinsHydrogen-Ion ConcentrationModels, MolecularOxygenProtein ConformationProtein StabilityTemperatureAcrylic Resinscarbopol 940ErythrocruorinsOxygenblood substitutesErythrocruorinhaemoglobinhaemoglobin based oxygen carrierHBOCpoly(acrylic acid)

Identifiers

PMID29916733
PMCPMC6476418

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.