ReviewESC heart failure2018
Sex, drugs, and heart failure: a sex-sensitive review of the evidence base behind current heart failure clinical guidelines.
Review in ESC heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Women's participation in stress management interventions for chronic heart failure: a meta-analysis of randomized controlled trials.Psychology, health & medicine · 2022Pooled it
- Sex-related differences in cardiovascular pharmacotherapy: fiction or fact? Why can't we see the evidence?European heart journal. Cardiovascular pharmacotherapy · 2025Review
- Sex Differences in 90-Day Readmission and Mortality Trends in Heart Failure With Preserved Ejection Fraction: Insights From the National Readmissions Database.International journal of heart failure · 2025Article
- A Study Of the effect of Sex on drug dosing, concentrations, and pharmacogenomics in the Montreal Heart Institute Hospital Cohort (SOS-PGx): methodology and research progress.European journal of clinical pharmacology · 2025Article
- Gender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health.Metabolites · 2023Review
- Heart Failure in the Elderly: the Role of Biological and Sociocultural Aspects Related to Sex.Current heart failure reports · 2023Review
- Sex Differences in Heart Failure: What Do We Know?Journal of cardiovascular development and disease · 2023Review
- Update on Management of Cardiovascular Diseases in Women.Journal of clinical medicine · 2022Review
- Sex differences in acute cardiovascular care: a review and needs assessment.Cardiovascular research · 2022Review
- Sexual dimorphism in cardiac remodeling: the molecular mechanisms ruled by sex hormones in the heart.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Trends in survival of Swedish men and women with heart failure from 1987 to 2014: a population-based case-control study.ESC heart failure · 2022Article
- Overexpression of NOX2 Exacerbates AngII-Mediated Cardiac Dysfunction and Metabolic Remodelling.Antioxidants (Basel, Switzerland) · 2022Article
- Sex related differences in the characteristics and outcomes of heart failure: A sub analysis of heart failure disease management study.Frontiers in cardiovascular medicine · 2022Article
- Association of heart failure and its comorbidities with loss of life expectancy.Heart (British Cardiac Society) · 2021Observational
- Discontinuation and non-publication of heart failure randomized controlled trials: a call to publish all trial results.ESC heart failure · 2021Article
- Heart failure in the last year: progress and perspective.ESC heart failure · 2020Review
- Sex differences in the evolution of left ventricle remodeling in rats with severe volume overload.BMC cardiovascular disorders · 2020Article
- Cardioprotective Effects of Dietary Phytochemicals on Oxidative Stress in Heart Failure by a Sex-Gender-Oriented Point of View.Oxidative medicine and cellular longevity · 2020Review
- Sex, drugs, and heart failure: a sex-sensitive review of the evidence base behind current heart failure clinical guidelines.ESC heart failure · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Heart failure (HF) is a complex disease, almost as common in women as in men. Nonetheless, HF clinical presentation, prognosis, and aetiology vary by sex. This review summarizes the current state of sex-sensitive issues related to HF drugs included in treatment guidelines and suggests future directions for improved care. Heart failure presentation differs between female and male patients: females more often show with hypertensive aetiology and the preserved ejection fraction phenotype, while men more often show ischaemic aetiology and the reduced ejection fraction phenotype. Yet the HF clinical guidelines in Europe, the United States, and Canada do not reflect the sexual dimorphism. Further, in randomized clinical trials of HF medication, women are largely underrepresented, typically consisting of ≥70% men. Given the knowledge that some adverse drug reactions, such as torsade de pointes and angiotensin-converting enzyme inhibitor-induced cough, occur more frequently in women, we emphasize the need to test medications thoroughly in both sexes and explore sexual dimorphisms. To better represent all of the targeted patient population and provide better care for all, two kinds of change must come about: recruitment methods to randomized clinical trial samples need to evolve and the participation needs to seem more attractive to women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.