Evidence map›Paper›PMID 29916116›Full record

ArticleMolecular imaging and biology2019

Noninvasive PET Imaging of a Ga-68-Radiolabeled RRL-Derived Peptide in Hepatocarcinoma Murine Models.

Yan Huo, Lei Kang, Xiaoxi Pang, Haoyuan Shen, Ping Yan, Chunli Zhang, Xuhe Liao, Xueqi Chen, Rongfu Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. ImmunoPET imaging of c-Met using a nanobody-based tracer [European journal of nuclear medicine and molecular imaging · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan HuoDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 St. Xishiku, Beijing, 100034, China.
Lei KangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 St. Xishiku, Beijing, 100034, China.
Xiaoxi PangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 St. Xishiku, Beijing, 100034, China.
Haoyuan ShenDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 St. Xishiku, Beijing, 100034, China.
Ping YanDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 St. Xishiku, Beijing, 100034, China.
Chunli ZhangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 St. Xishiku, Beijing, 100034, China.
Xuhe LiaoDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 St. Xishiku, Beijing, 100034, China.
Xueqi ChenDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 St. Xishiku, Beijing, 100034, China.
Rongfu WangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 St. Xishiku, Beijing, 100034, China. rongfu_wang2003@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTc-99m- and I-131-labeled arginine-arginine-leucine (RRL) peptides have shown the feasibility of tumor imaging in our previous studies. However, there have been no reports using RRL peptide for positron emission tomography (PET) imaging. In this study, RRL was radiolabeled with Ga-68 under optimized reaction conditions to develop a better specific and effective tumor imaging agent. PROCEDURES: RRL was synthesized and conjugated to a bifunctional chelating agent (DOTA-NHS), then radiolabeled with Ga-68. Labeling yield was optimized by varying pH, temperature, and reaction time and the stability was evaluated in human fresh serum. Cellular uptakes of [

resultsThe labeling yield of [

conclusionsOur study successfully prepared [

Indexed as

Positron-Emission TomographyAnimalsCarcinoma, HepatocellularCell Line, TumorDisease Models, AnimalGallium RadioisotopesHumansLiver NeoplasmsMicePeptidesTissue DistributionGallium-68Gallium RadioisotopesPeptidesArginine-arginine-leucine (RRL)Gallium-68 (68Ga)HepatocarcinomaMolecular imagingPeptide

Identifiers

PMID29916116

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.