Evidence map›Paper›PMID 29916009›Full record

ArticleClinical and translational medicine2018

Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator.

Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A Cox, Marla R Wolfson, Thomas H Shaffer, Robert O Williams, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Asiaticoside attenuates hyperoxia-induced lung injuryIranian journal of basic medical sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Satoshi FukudaTranslational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
Perenlei EnkhbaatarTranslational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
Christina NelsonTranslational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
Robert A CoxTranslational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
Marla R WolfsonDepartment of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Thomas H ShafferCenter for Pediatric Lung Research, Alfred I. DuPont Hospital for Children, Wilmington, DE, USA.
Robert O WilliamsMolecular Pharmaceutics and Drug Delivery, The University of Texas at Austin, Austin, TX, USA.
Soraya Hengsawas SurasarangMolecular Pharmaceutics and Drug Delivery, The University of Texas at Austin, Austin, TX, USA.
Sahakijpijarn SawittreeMolecular Pharmaceutics and Drug Delivery, The University of Texas at Austin, Austin, TX, USA.
Galina FlorovaThe Department of Cellular and Molecular Biology and the Texas Lung Institute, The University of Texas Health Science Center at Tyler, 11927 US HWY 271, Tyler, TX, 75708, USA.
Andrey A KomissarovThe Department of Cellular and Molecular Biology and the Texas Lung Institute, The University of Texas Health Science Center at Tyler, 11927 US HWY 271, Tyler, TX, 75708, USA.
Kathleen KoenigThe Department of Cellular and Molecular Biology and the Texas Lung Institute, The University of Texas Health Science Center at Tyler, 11927 US HWY 271, Tyler, TX, 75708, USA.
Krishna SarvaThe Department of Cellular and Molecular Biology and the Texas Lung Institute, The University of Texas Health Science Center at Tyler, 11927 US HWY 271, Tyler, TX, 75708, USA.
Harrison T NdetanThe Department of Epidemiology and Biostatistics, The University of Texas Health Science Center at Tyler, 11927 US HWY 271, Tyler, TX, 75708, USA.
Karan P SinghThe Department of Epidemiology and Biostatistics, The University of Texas Health Science Center at Tyler, 11927 US HWY 271, Tyler, TX, 75708, USA.
Steven IdellThe Department of Cellular and Molecular Biology and the Texas Lung Institute, The University of Texas Health Science Center at Tyler, 11927 US HWY 271, Tyler, TX, 75708, USA. steven.idell@uthct.edu.
The University of Texas Health Science Center at Tyler · USThe University of Texas Medical Branch at Galveston · USLung Institute · USThe University of Texas at Austin · USDuPont (United States) · USTemple University · US

Funding

Photonics Monitoring and Modeling CoreU54ES027698 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI WHITE, CARL W · 2016 to 2021
$16.7M
Airway Delivery of Fibrinolytic Therapy for ISALIR01HL118401 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI ENKHBAATAR, PERENLEI, IDELL, STEVEN · 2014 to 2017
$3.0M
Foundation for the National Institutes of Health ES027698NHLBI NIH HHS 118401NHLBI NIH HHS HHSN268201100014CNHLBI NIH HHS R01 HL118401NIAMS NIH HHS HHSN268201100014INIEHS NIH HHS U54 ES027698
6 · The paper itself

Abstract

backgroundAirway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking. Nebulized anticoagulants or a tissue plasminogen activator; tPA, has been advocated, but airway bleeding is a known and lethal potential complication. We posited that nebulized delivery of single chain urokinase plasminogen activator, scuPA, is well-tolerated and improves physiologic outcomes in ISIALI. To test this hypothesis, we nebulized scuPA or tPA and delivered these agents every 4 h to sheep with cotton smoke induced ISIALI that were ventilated by either adaptive pressure ventilation/controlled mandatory ventilation (APVcmv; Group 1, n = 14) or synchronized controlled mandatory ventilation (SCMV)/limited suctioning; Group 2, n = 32). Physiologic readouts of acute lung injury included arterial blood gas analyses, PaO

resultsIn Group 1, tPA at the 2 mg dose was ineffective, but at 4 mg tPA or scuPA, the PaO

conclusionsPhysiologic outcomes improved in sheep in which better delivery of the PAs occurred. The benefits of nebulized scuPA were achieved without airway bleeding associated with tPA, but were transient and largely abrogated at 48 h, in part attributable to the progression and severity of ISIALI.

Indexed as

FibrinolysinsInhalational acute lung injuryPlasminogen activator inhibitor-1Plasminogen activators

Identifiers

PMID29916009
PMCPMC6006005
OpenAlexW2809041189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.