Evidence map›Paper›PMID 29915997›Full record

ArticleJournal of industrial microbiology & biotechnology2018

Synthetic biology advances and applications in the biotechnology industry: a perspective.

Leonard Katz, Yvonne Y Chen, Ramon Gonzalez, Todd C Peterson, Huimin Zhao, Richard H Baltz

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of industrial microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Bioengineering hybrid artificial life.Frontiers in bioinformatics · 2025
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Metabolic engineering ofSynthetic and systems biotechnology · 2023
    Article
  15. Review
  16. Review
  17. Engineering ofInternational journal of molecular sciences · 2022
    Article
  18. Precursor Quantitation Methods for Next Generation Food Production.Frontiers in bioengineering and biotechnology · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leonard KatzQB3 Institute, University of California-Berkeley, 5885 Hollis St., 4th Floor, Emeryville, CA, 94608, USA.
Yvonne Y ChenDepartment of Chemical and Biomolecular Engineering, University of California-Los Angeles, 420 Westwood Plaza, Boelter Hall 5531, Los Angeles, CA, 90095, USA.
Ramon GonzalezDepartments of Chemical and Biomolecular Engineering and Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA.
Todd C PetersonSynthetic Genomics, Inc., 11149 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Huimin ZhaoDepartment of Chemical and Biomolecular Engineering, University of Illinois, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Richard H BaltzCognoGen Biotechnology Consulting, 7636 Andora Drive, Sarasota, FL, 34238, USA. rbaltz923@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic biology is a logical extension of what has been called recombinant DNA (rDNA) technology or genetic engineering since the 1970s. As rDNA technology has been the driver for the development of a thriving biotechnology industry today, starting with the commercialization of biosynthetic human insulin in the early 1980s, synthetic biology has the potential to take the industry to new heights in the coming years. Synthetic biology advances have been driven by dramatic cost reductions in DNA sequencing and DNA synthesis; by the development of sophisticated tools for genome editing, such as CRISPR/Cas9; and by advances in informatics, computational tools, and infrastructure to facilitate and scale analysis and design. Synthetic biology approaches have already been applied to the metabolic engineering of microorganisms for the production of industrially important chemicals and for the engineering of human cells to treat medical disorders. It also shows great promise to accelerate the discovery and development of novel secondary metabolites from microorganisms through traditional, engineered, and combinatorial biosynthesis. We anticipate that synthetic biology will continue to have broadening impacts on the biotechnology industry to address ongoing issues of human health, world food supply, renewable energy, and industrial chemicals and enzymes.

Indexed as

Metabolic EngineeringActinobacteriaAnimalsBiosensing TechniquesBiotechnologyCHO CellsCricetulusCRISPR-Associated Protein 9DNA FragmentationEscherichia coliGene EditingGene Expression RegulationHumansIndustrySaccharomyces cerevisiaeSynthetic BiologyCRISPR-Associated Protein 9BiosensorsBiotechnology industryCombinatorial biosynthesisCRISPR/Cas9DNA assemblyDNA synthesisMammalian cellsMetabolic engineeringNatural productsSynthetic biology

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.