Evidence map›Paper›PMID 29915934›Full record

ArticleThe journal of headache and pain2018

Novel capsaicin-induced parameters of microcirculation in migraine patients revealed by imaging photoplethysmography.

Alexei A Kamshilin, Maxim A Volynsky, Olga Khayrutdinova, Dilyara Nurkhametova, Laura Babayan, Alexander V Amelin, Oleg V Mamontov, Rashid Giniatullin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Alexei A KamshilinDepartment of Computer Photonics and Videomatics, ITMO University, St. Petersburg, Russia. alexei.kamshilin@yandex.ru.ORCID http://orcid.org/0000-0003-2506-9736
Maxim A VolynskyDepartment of Computer Photonics and Videomatics, ITMO University, St. Petersburg, Russia.
Olga KhayrutdinovaDepartment of Neurology and Rehabilitation, Kazan State Medical University, Kazan, Russia.
Dilyara NurkhametovaLaboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
Laura BabayanDepartment of Neurology and Neurosurgery, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.
Alexander V AmelinDepartment of Neurology and Neurosurgery, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.
Oleg V MamontovDepartment of Computer Photonics and Videomatics, ITMO University, St. Petersburg, Russia.
Rashid GiniatullinDepartment of Computer Photonics and Videomatics, ITMO University, St. Petersburg, Russia.
ITMO University · RUFirst Pavlov State Medical University of St. Petersburg · RUKazan State Medical University · RUUniversity of Eastern Finland · FI

Funding

Russian Science Foundation 15-15-20012
6 · The paper itself

Abstract

backgroundThe non-invasive biomarkers of migraine can help to develop the personalized medication of this disorder. In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors in sensory neurons associated with the release of the migraine mediator CGRP has already been widely used.

methodsFourteen migraine patients (mean age 34.6 ± 10.2 years) and 14 healthy volunteers (mean age 29.9 ± 9.7 years) participated in the experiment. A new arrangement of imaging photoplethysmography recently developed by us was used here to discover novel sensitive parameters of dermal blood flow during capsaicin applications in migraine patients.

resultsBlood pulsation amplitude (BPA) observed as optical-intensity waveform varying synchronously with heartbeat was used for detailed exploration of microcirculatory perfusion induced by capsicum patch application. The BPA signals, once having appeared after certain latent period, were progressively rising until being saturated. Capsaicin-induced high BPA areas were distributed unevenly under the patch, forming "hot spots." Interestingly the hot spots were much more variable in migraine patients than in the control group. In contrast to BPA, a slow component of waveforms related to the skin redness changed significantly less than BPA highlighting the latter parameter as the potential sensitive biomarker of capsaicin-induced activation of the blood flow. Thus, in migraine patients, there is a non-uniform (both in space and in time) reaction to capsaicin, resulting in highly variable openings of skin capillaries.

conclusionBPA dynamics measured by imaging photoplethysmography could serve as a novel sensitive non-invasive biomarker of migraine-associated changes in microcirculation.

Indexed as

PhotoplethysmographyAdultCapsaicinFemaleHumansMaleMicrocirculationMiddle AgedMigraine DisordersSkinYoung AdultCapsaicinCapsaicinCGRPDermal blood flowImaging photoplethysmographyMicrocirculationMigraineTRPV1

Identifiers

PMID29915934
PMCPMC6005996
OpenAlexW2808991760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.