ArticleEuropean radiology2019
Diagnosis of diffuse spleen involvement in haematological malignancies using a spleen-to-liver attenuation ratio on contrast-enhanced CT images.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Radiological Approach to Splenomegaly: Etiologies, Pathophysiologies, and Diagnostic Strategies.Korean journal of radiology · 2026Review
- Discrimination of myelofibrosis and liver cirrhosis using a spleen ultrasound-based radiomics nomogram model.Experimental and therapeutic medicine · 2025Article
- Diagnostic ability of [European radiology · 2025Article
- The value of radiomics features of the spleen as surrogates for differentiating subtypes of common pediatric lymphomas.Quantitative imaging in medicine and surgery · 2024Article
- Intravoxel incoherent motion diffusion-weighted MRI for the evaluation of early spleen involvement in acute leukemia.Quantitative imaging in medicine and surgery · 2024Article
- Machine Learning Radiomics Signature for Differentiating Lymphoma versus Benign Splenomegaly on CT.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Comparison of whole-body MRI with diffusion-weighted imaging and PET/CT in lymphoma staging.European radiology · 2020Article
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Authors and funding
5 authors.
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Abstract
objectivesWe aimed to test the hypothesis that the spleen-to-liver-attenuation ratio on portal-venous enhancement phase CT images can identify diffuse splenic infiltration in subjects with lymphoma.
methodsA database search yielded 70 subjects with malignant haematological diseases who underwent contrast-enhanced CT (CECT) between December 2010 and March 2018. Additionally, consecutive control subjects were evaluated. We compared the splenic volume, splenic attenuation, spleen-to-liver, spleen-to-aorta and spleen-to-musculature ratios on portal-venous phase CECT images, pre- to post-treatment and between the different lymphoma entities. The standard of reference for splenic involvement was normalisation of the spleen volume following chemotherapy or normalisation of FDG-uptake.
resultsIn subjects with diffuse splenic involvement, the spleen attenuation was significantly lower before treatment (93.48 HU) compared to controls (112.39 HU; p < .01) and after successful treatment (113.39 HU; p < .01). The spleen-to-liver attenuation ratio significantly increased after treatment (p < .001) and proved significantly lower at baseline when compared to control subjects (p < .01). The spleen volume significantly decreased after successful treatment (from 586.14.87 cm
conclusionsWe suggest the additional use of spleen-to-liver attenuation ratio to splenic volume alone for detection of diffuse splenic infiltration in subjects with lymphoma. The course of spleen-to-liver attenuation ratio inversely correlated with that of FDG-uptake in a subgroup of patients working accurately in normal-sized diffusely involved spleens. KEY POINTS: • Involvement of the spleen is frequent in haematological malignancies and is important for staging and appropriate treatment. • Diffuse splenic infiltration often results in only homogeneous splenomegaly without a focal lesion, but even no or only minimal increase in splenic volume is possible. In these cases diagnosis of spleen involvement is a challenge for the radiologist. • Our data support the use of the spleen-to-liver attenuation ratio in addition to size measurements for the detection of diffuse splenic infiltration in subjects with lymphoma.
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