Trial reportEuropean journal of pediatrics2018
Using a high-flow nasal cannula provides superior results to OxyMask delivery in moderate to severe bronchiolitis: a randomized controlled study.
Trial report in European journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 9 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Pooled it
- Respiratory support in paediatric patients with bronchiolitis: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Application of the TIDieR checklist to improve the HFNC use in bronchiolitis management.European journal of pediatrics · 2024Pooled it
- High-flow nasal cannula therapy for infants with bronchiolitis.The Cochrane database of systematic reviews · 2024Pooled it
- High flow nasal cannula for respiratory support in term infants.The Cochrane database of systematic reviews · 2023Pooled it
- Efficacy and safety of high flow nasal oxygen for children with bronchiolitis: systematic review and meta-analysis.BMJ open respiratory research · 2021Pooled it
- LOCATE: a prospective evaluation of the value of Leveraging Ongoing Citation Acquisition Techniques for living Evidence syntheses.Systematic reviews · 2021Pooled it
- Non-Invasive Ventilation Strategies in Children With Acute Lower Respiratory Infection: A Systematic Review and Bayesian Network Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- High flow nasal cannula as respiratory support in treating infant bronchiolitis: a systematic review.European journal of pediatrics · 2020Pooled it
- Review
- Non-invasive respiratory support in pediatric patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis of randomized controlled trials.EClinicalMedicine · 2025Article
- Application of the 2023 Italian guidelines for respiratory support management in acute viral bronchiolitis: a retrospective study.BMJ paediatrics open · 2025Observational
- Article
- Predictors of high-flow nasal cannula failure in pediatric patients with acute respiratory distress.Clinical and experimental pediatrics · 2022Article
- Superiority of OxyMaskEuropean journal of pediatrics · 2021Article
- The cost-utility of early use of high-flow nasal cannula in bronchiolitis.Health economics review · 2021Article
- Update on the Role of High-Flow Nasal Cannula in Infants with Bronchiolitis.Children (Basel, Switzerland) · 2021Review
- Nasal high flow higher than 60 L/min in patients with acute hypoxemic respiratory failure: a physiological study.Critical care (London, England) · 2020Article
- Decision-making in acute viral bronchiolitis: A universal guideline and a publication gap.PloS one · 2020Article
- Use of high-flow nasal cannula in infants with viral bronchiolitis outside pediatric intensive care units.European journal of pediatrics · 2019Observational
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effectiveness of using a face mask with a small diffuser for oxygen delivery (OxyMask) was compared to use of a high-flow nasal cannula (HFNC) in patients with moderate or severe bronchiolitis.The study population in this open, phase 4, randomized controlled trial consisted of 60 patients aged 1-24 months diagnosed with moderate or severe bronchiolitis and admitted to an intensive care unit (ICU) for oxygen therapy. The patients were randomized into two groups according to the method of oxygen delivery: a diffuser mask group and an HFNC group.There were seven failures in the mask group and none in the HFNC group. The survival probability differed significantly between the two treatment methods (p = 0.009).Time to weaning off oxygen therapy was 56 h in the HFNC group and 96 h in the mask group (p < 0.001).Conclusion: HFNC use decreased the treatment failure rate and the duration of both oxygen therapy and ICU treatment compared to the diffuser mask, which implies that an HFNC should be the first choice for treating patients admitted to the ICU with severe bronchiolitis. What is known: • A high-flow nasal cannula (HFNC) does not significantly reduce the time on oxygen compared to standard therapy in children with moderate to severe bronchiolitis. Observational studies show that, since the introduction of HFNC, fewer children with bronchiolitis need intubation. For children with moderate to severe bronchiolitis there is no proof of its benefit. What Is New: • In children with moderate to severe bronchiolitis, HFNC provides faster and more effective improvement than can be achieved with a diffuser mask.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.