Evidence map›Paper›PMID 29915595›Full record

ReviewFrontiers in immunology2018

Dysregulated MicroRNA Involvement in Multiple Sclerosis by Induction of T Helper 17 Cell Differentiation.

Chen Chen, Yifan Zhou, Jingqi Wang, Yaping Yan, Lisheng Peng, Wei Qiu

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04300543 (MicroRNA-150 and microRNA-155 as Molecular Biomarkers in Multiple Sclerosis), which is not on this map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04300543 unknown statusnot on this mapstarted 2020, after this paper: background citation

MicroRNA-150 and microRNA-155 as Molecular Biomarkers in Multiple Sclerosis

TypeobservationalSponsorAssiut UniversityRan2020 to 2021Enrolled140ConditionsMultiple Sclerosis
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  3. Review
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  18. Article
  19. MicroRNAs, Multiple Sclerosis, and Depression.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chen ChenDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yifan ZhouDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jingqi WangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yaping YanDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Lisheng PengDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Wei QiuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Sun Yat-sen University · CNThird Affiliated Hospital of Sun Yat-sen University · CNShaanxi Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Growing evidence has proven that T helper 17 (Th17) cells are one of the regulators of neuroinflammation mechanisms in MS disease. Researchers have demonstrated that some microRNAs (miRNAs) are associated with disease activity and duration, even with different MS patterns. miRNAs regulate CD4

Indexed as

AnimalsCell DifferentiationDisease Models, AnimalDisease SusceptibilityEncephalomyelitis, Autoimmune, ExperimentalGene Expression RegulationHumansImmunomodulationLymphocyte ActivationMicroRNAsMultiple SclerosisSignal TransductionTh17 CellsT-Lymphocyte SubsetsMicroRNAsexperimental autoimmune encephalomyelitismicroRNAmultiple sclerosisT helper 17 cellstreatment

Identifiers

PMID29915595
PMCPMC5994557
OpenAlexW2803461783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.