Evidence map›Paper›PMID 29915536›Full record

ArticleFrontiers in pharmacology2018

Use of Submicron Vaterite Particles Serves as an Effective Delivery Vehicle to the Respiratory Portion of the Lung.

Olga Gusliakova, Elena N Atochina-Vasserman, Olga Sindeeva, Sergey Sindeev, Sergey Pinyaev, Nikolay Pyataev, Viktor Revin, Gleb B Sukhorukov, Dmitry Gorin, Andrew J Gow

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 39 citations in OpenAlex.

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  10. Magneto-Fluorescent Hybrid Sensor CaCOMaterials (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Olga GusliakovaRemote Controlled Theranostic Systems Lab, Saratov State University, Saratov, Russia.
Elena N Atochina-VassermanRASA Center in Tomsk, Tomsk Polytechnic University, Tomsk, Russia.
Olga SindeevaRemote Controlled Theranostic Systems Lab, Saratov State University, Saratov, Russia.
Sergey SindeevRemote Controlled Theranostic Systems Lab, Saratov State University, Saratov, Russia.
Sergey PinyaevDepartment of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia.
Nikolay PyataevDepartment of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia.
Viktor RevinDepartment of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia.
Gleb B SukhorukovRemote Controlled Theranostic Systems Lab, Saratov State University, Saratov, Russia.
Dmitry GorinRemote Controlled Theranostic Systems Lab, Saratov State University, Saratov, Russia.
Andrew J GowRASA Center in Tomsk, Tomsk Polytechnic University, Tomsk, Russia.
Saratov State University · RUNational Research Mordovia State University · RUNational Research Tomsk State University · RUQueen Mary University of London · GB

Funding

NO-Modified Biomolecules and Pulmonary SignalingR01HL086621 · NHLBI · RUTGERS, THE STATE UNIV OF N.J. · PI GOW, ANDREW J · 2008 to 2016
$2.8M
NHLBI NIH HHS R01 HL086621
6 · The paper itself

Abstract

Nano- and microencapsulation has proven to be a useful technique for the construction of drug delivery vehicles for use in vascular medicine. However, the possibility of using these techniques within the lung as an inhalation delivery mechanism has not been previously considered. A critical element of particle delivery to the lung is the degree of penetrance that can be achieved with respect to the airway tree. In this study we examined the effectiveness of near infrared (NIR) dye (Cy7) labeled calcium carbonate (vaterite) particles of 3.15, 1.35, and 0.65 μm diameter in reaching the respiratory portion of the lung. First of all, it was shown that, interaction vaterite particles and the components of the pulmonary surfactant occurs a very strong retardation of the recrystallization and dissolution of the particles, which can subsequently be used to create systems with a prolonging release of bioactive substances after the particles penetrate the distal sections of the lungs. Submicro- and microparticles, coated with Cy7 labeled albumin as a model compound, were delivered to mouse lungs via tracheostomy with subsequent imaging performed 24, 48, and 72 h after delivery by

Indexed as

drug carriersprolonging releasepulmonary drug deliverysize-dependent biodistributionvaterite particles

Identifiers

PMID29915536
PMCPMC5994594
OpenAlexW2799979760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.