ArticleFrontiers in systems neuroscience2018
Engineering Artificial Somatosensation Through Cortical Stimulation in Humans.
Article in Frontiers in systems neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Intracortical Somatosensory Stimulation to Elicit Fingertip Sensations in an Individual With Spinal Cord Injury.Neurology · 2022Trial
- Direct stimulation of somatosensory cortex results in slower reaction times compared to peripheral touch in humans.Scientific reports · 2019Trial
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Human tactile sensing and sensorimotor mechanism: from afferent tactile signals to efferent motor control.Nature communications · 2024Article
- Sensory Restoration for Improved Motor Control of Prostheses.Current opinion in biomedical engineering · 2023Article
- Neuroprosthetics: from sensorimotor to cognitive disorders.Communications biology · 2023Review
- Corticospinal interface to restore voluntary control of joint torque in a paralyzed forearm following spinal cord injury in non-human primates.Frontiers in neuroscience · 2023Article
- Artifact propagation in subdural cortical electrostimulation: Characterization and modeling.Frontiers in neuroscience · 2022Article
- Benchtop and bedside validation of a low-cost programmable cortical stimulator in a testbed for bi-directional brain-computer-interface research.Frontiers in neuroscience · 2022Article
- Developing control-theoretic objectives for large-scale brain dynamics and cognitive enhancement.Annual reviews in control · 2022Article
- Workshops of the Eighth International Brain-Computer Interface Meeting: BCIs: The Next Frontier.Brain computer interfaces (Abingdon, England) · 2022Article
- MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation.Science translational medicine · 2021Article
- Historical perspectives, challenges, and future directions of implantable brain-computer interfaces for sensorimotor applications.Bioelectronic medicine · 2021Review
- Encoding of limb state by single neurons in the cuneate nucleus of awake monkeys.Journal of neurophysiology · 2021Article
- A brain-computer interface that evokes tactile sensations improves robotic arm control.Science (New York, N.Y.) · 2021Article
- A Roadmap Towards Standards for Neurally Controlled End Effectors.IEEE open journal of engineering in medicine and biology · 2021Article
- Signal recovery from stimulation artifacts in intracranial recordings with dictionary learning.Journal of neural engineering · 2020Article
- Utility and lower limits of frequency detection in surface electrode stimulation for somatosensory brain-computer interface in humans.Neurosurgical focus · 2020Article
- The frequency of cortical microstimulation shapes artificial touch.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Short reaction times in response to multi-electrode intracortical microstimulation may provide a basis for rapid movement-related feedback.Journal of neural engineering · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
Sensory feedback is a critical aspect of motor control rehabilitation following paralysis or amputation. Current human studies have demonstrated the ability to deliver some of this sensory information via brain-machine interfaces, although further testing is needed to understand the stimulation parameters effect on sensation. Here, we report a systematic evaluation of somatosensory restoration in humans, using cortical stimulation with subdural mini-electrocorticography (mini-ECoG) grids. Nine epilepsy patients undergoing implantation of cortical electrodes for seizure localization were also implanted with a subdural 64-channel mini-ECoG grid over the hand area of the primary somatosensory cortex (S1). We mapped the somatotopic location and size of receptive fields evoked by stimulation of individual channels of the mini-ECoG grid. We determined the effects on perception by varying stimulus parameters of pulse width, current amplitude, and frequency. Finally, a target localization task was used to demonstrate the use of artificial sensation in a behavioral task. We found a replicable somatotopic representation of the hand on the mini-ECoG grid across most subjects during electrical stimulation. The stimulus-evoked sensations were usually of artificial quality, but in some cases were more natural and of a cutaneous or proprioceptive nature. Increases in pulse width, current strength and frequency generally produced similar quality sensations at the same somatotopic location, but with a perception of increased intensity. The subjects produced near perfect performance when using the evoked sensory information in target acquisition tasks. These findings indicate that electrical stimulation of somatosensory cortex through mini-ECoG grids has considerable potential for restoring useful sensation to patients with paralysis and amputation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.