ArticleScientific reports2018
Uncovering global metabolic response to cordycepin production in Cordyceps militaris through transcriptome and genome-scale network-driven analysis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Influence of Culture Conditions on Bioactive Compounds inFoods (Basel, Switzerland) · 2025Review
- A Review of Genomic, Transcriptomic, and Proteomic Applications in Edible Fungi Biology: Current Status and Future Directions.Journal of fungi (Basel, Switzerland) · 2025Review
- A novel complementary pathway of cordycepin biosynthesis in Cordyceps militaris.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Advances in biosynthesis and metabolic engineering strategies of cordycepin.Frontiers in microbiology · 2024Review
- Increasing the production of the bioactive compounds in medicinal mushrooms: an omics perspective.Microbial cell factories · 2023Review
- Transcriptome and metabolome profiling unveils the mechanisms of naphthalene acetic acid in promoting cordycepin synthesis inFrontiers in nutrition · 2023Article
- Enhancing Genome-Scale Model by Integrative Exometabolome and Transcriptome: Unveiling Carbon Assimilation towards Sphingolipid Biosynthetic Capability ofJournal of fungi (Basel, Switzerland) · 2022Article
- Construction of Light-Responsive Gene Regulatory Network for Growth, Development and Secondary Metabolite Production inBiology · 2022Article
- Comprehensive Transcriptomic Analysis ofMycobiology · 2022Review
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- Probing Carbon Utilization ofCells · 2020Article
- Transcriptome Analysis Reveals the Flexibility of Cordycepin Network inFrontiers in microbiology · 2020Article
- Optimizing cultivation ofComputational and structural biotechnology journal · 2020Article
- Transcriptome and proteome analyses reveal the regulatory networks and metabolite biosynthesis pathways during the development ofComputational and structural biotechnology journal · 2020Article
- Improved Cordycepin Production byBiomolecules · 2019Article
- Metabolomic profiling reveals enrichment of cordycepin in senescence process of Cordyceps militaris fruit bodies.Journal of microbiology (Seoul, Korea) · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular metabolic adaptations of Cordyceps militaris have been progressively studied. In particular, the cordycepin pathway is of interest in medicinal applications. Even though the metabolic pathways for cordycepin production are known to be related to different carbon sources, the regulatory mechanisms at a systems level are poorly characterized. To explore the regulatory mechanisms, this study therefore aimed to investigate the global metabolic response to cordycepin production in C. militaris through transcriptome analysis and genome-scale network-driven analysis. Here, transcriptome analysis of 16,805 expressed genes in C. militaris strain TBRC6039 grown on different carbon sources was performed. Of these genes, 2,883 were significantly differentially expressed genes, uncovering sucrose- and glucose-mediated changes in the transcriptional regulation of central carbon metabolism in C. militaris, which was shown using the CmSNF1 mechanism as an example. After applying genome-scale metabolic network-driven analysis, reporter metabolites and key metabolic subnetworks involving adenosine, cordycepin and methionine were proposed through the up-regulation of cordycepin biosynthetic genes. Our findings suggest that the transcriptional regulation of these pathways is a ubiquitous feature in response to specific culture conditions during cordycepin overproduction.
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