ArticleNature chemistry2018
A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]
Article in Nature chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Iron-sulfur cofactors in nucleic acid metabolism and protein synthesis: Assembly, delivery, and putative roles in cellular and viral systems.The Journal of biological chemistry · 2026Review
- Effects of LED phototherapy on oxidative damage in hyperbilirubinemia neonates.BMC pediatrics · 2026Article
- Crystal structure of MutYX: a novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-oxoguanine recognition sphere.Nucleic acids research · 2025Article
- Saturation mapping of MUTYH variant effects using DNA repair reporters.American journal of human genetics · 2025Article
- Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair.Nature communications · 2025Article
- Prevalence of germline mutations in cancer susceptibility genes in Chinese patients with renal cell carcinoma.Translational andrology and urology · 2023Article
- Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer.Scientific reports · 2022Article
- Review
- Walking around Ribosomal Small Subunit: A Possible "Tourist Map" for Electron Holes.Molecules (Basel, Switzerland) · 2021Article
- Tuning of Molecular Electrostatic Potential Enables Efficient Charge Transport in Crystalline Azaacenes: A Computational Study.International journal of molecular sciences · 2020Article
- UvrC Coordinates an OJournal of the American Chemical Society · 2020Article
- When you're strange: Unusual features of the MUTYH glycosylase and implications in cancer.DNA repair · 2019Review
- Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles.Journal of the American Chemical Society · 2019Article
- Redox Chemistry in the Genome: Emergence of the [4Fe4S] Cofactor in Repair and Replication.Annual review of biochemistry · 2019Review
- Effective Distance for DNA-Mediated Charge Transport between Repair Proteins.ACS central science · 2019Article
- Yeast require redox switching in DNA primase.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Substrate Binding Regulates Redox Signaling in Human DNA Primase.Journal of the American Chemical Society · 2018Article
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
The human DNA repair enzyme MUTYH excises mispaired adenine residues in oxidized DNA. Homozygous MUTYH mutations underlie the autosomal, recessive cancer syndrome MUTYH-associated polyposis. We report a MUTYH variant, p.C306W (c.918C>G), with a tryptophan residue in place of native cysteine, that ligates the [4Fe4S] cluster in a patient with colonic polyposis and family history of early age colon cancer. In bacterial MutY, the [4Fe4S] cluster is redox active, allowing rapid localization to target lesions by long-range, DNA-mediated signalling. In the current study, using DNA electrochemistry, we determine that wild-type MUTYH is similarly redox-active, but MUTYH C306W undergoes rapid oxidative degradation of its cluster to [3Fe4S]
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