Evidence map›Paper›PMID 29915261›Full record

ArticleScientific reports2018

Molecular signature of progenitor cells isolated from young and adult human hearts.

Ann-Sophie Walravens, Maarten Vanhaverbeke, Lara Ottaviani, Hilde Gillijns, Sander Trenson, Nina Vanden Driessche, Aernout Luttun, Bart Meyns, Paul Herijgers, Filip Rega and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Stem Cell Therapy Targets: Repêchage!Circulation research · 2022
    Article
  4. Cardiac Progenitor Cells.Advances in experimental medicine and biology · 2021
    Review
  5. Article
  6. Secretome Analysis Performed DuringFrontiers in cell and developmental biology · 2020
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ann-Sophie WalravensDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.ORCID 0000-0003-3895-0549
Maarten VanhaverbekeDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.ORCID 0000-0002-4385-7069
Lara OttavianiDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.
Hilde GillijnsDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.
Sander TrensonDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.
Nina Vanden DriesscheDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.
Aernout LuttunDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.
Bart MeynsDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.
Paul HerijgersDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.ORCID 0000-0003-0951-8132
Filip RegaDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.
Ruth HeyingDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium.
Maurilio SampaolesiDepartment of Development and Regeneration, KU Leuven, 3000, Leuven, Belgium.ORCID 0000-0002-2422-3757
Stefan JanssensDepartment of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium. stefan.janssens@kuleuven.be.
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The loss of endogenous cardiac regenerative capacity within the first week of postnatal life has intensified clinical trials to induce cardiac regeneration in the adult mammalian heart using different progenitor cell types. We hypothesized that donor age-related phenotypic and functional characteristics of cardiac progenitor cells (CPC) account for mixed results of cell-based cardiac repair. We compared expression profiles and cell turnover rates of human heart-derived c-kit

Indexed as

Cell SeparationGene Expression ProfilingAdultAgedAged, 80 and overCell DifferentiationCell ProliferationCell ShapeDown-RegulationFemaleHumansMaleMiddle AgedMyocardiumNeovascularization, PhysiologicPhenotypeProto-Oncogene Proteins c-kit

Identifiers

PMID29915261
PMCPMC6006291
OpenAlexW2807995500

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.