Evidence map›Paper›PMID 29915258›Full record

ArticleNature communications2018

A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas.

Shai Rosenberg, Iva Simeonova, Franck Bielle, Maite Verreault, Bertille Bance, Isabelle Le Roux, Mailys Daniau, Arun Nadaradjane, Vincent Gleize, Sophie Paris and 16 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. The chordoid gliomaScience signaling · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Glioma.Nature reviews. Disease primers · 2024
    Review
  11. Review
  12. Review
  13. Major Features of the 2021 WHO Classification of CNS Tumors.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 9 institutions in 4 countries.

Shai RosenbergInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.ORCID http://orcid.org/0000-0001-6309-6933
Iva SimeonovaInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Franck BielleInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Maite VerreaultInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Bertille BanceInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Isabelle Le RouxInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Mailys DaniauInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Arun NadaradjaneInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Vincent GleizeInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Sophie ParisInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Yannick MarieInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Marine GiryInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Marc PolivkaDepartment of Pathology, AP-HP, Hôpital Lariboisière, F-75010, Paris, France.
Dominique Figarella-BrangerPathology and Neuropathology Department, Assistance Publique-Hôpitaux de Marseille (AP-HM), CHU Timone, 13005, Marseille, France.
Marie-Hélène Aubriot-LortonDepartment of Pathology and CRB Ferdinand Cabanne, CHU Dijon Bourgogne, 21000, Dijon, France.
Chiara VillaDepartment of Pathological Cytology and Anatomy, Foch Hospital, Suresnes, F-92151, Paris, France.
Alexandre VasiljevicCentre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, 69500, Bron, France.
Emmanuèle Lechapt-ZalcmanDepartment of Pathology, CHU de Caen, Caen, France Normandie Univ, UNICAEN, CEA, CNRS, ISTCT/LDM-TEP Group, 14000, Caen, France.
Michel KalamaridesInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Ariane SharifINSERM U1172, "Development and Plasticity of the Neuroendocrine Brain", F-59045, Lille, France.
Karima MokhtariInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Stefano Maria PagnottaDipartimento di Scienze e Tecnologie, Università degli Studi del Sannio, 82100, Benevento, Italy.
Antonio IavaroneInstitute for Cancer Genetics, Columbia University Medical Center, New York City, NY, 10032, USA.
Anna LasorellaInstitute for Cancer Genetics, Columbia University Medical Center, New York City, NY, 10032, USA.
Emmanuelle HuillardInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France.
Marc SansonInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM, F-75013, Paris, France. marc.sanson@aphp.fr.
Centre National de la Recherche Scientifique · FRColumbia University Irving Medical Center · USAssistance Publique Hôpitaux de Marseille · FRAssistance Publique – Hôpitaux de Paris · FRHôpital Foch · FRHospices Civils de Lyon · FRInserm · FRUniversité de Bourgogne · FRUniversity of Sannio · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chordoid glioma (ChG) is a characteristic, slow growing, and well-circumscribed diencephalic tumor, whose mutational landscape is unknown. Here we report the analysis of 16 ChG by whole-exome and RNA-sequencing. We found that 15 ChG harbor the same PRKCA

Indexed as

AdultAgedCell ProliferationCells, CulturedCerebral Ventricle NeoplasmsFemaleGliomaHumansMaleMiddle AgedPoint MutationProtein Kinase C-alphaPRKCA protein, humanProtein Kinase C-alpha

Identifiers

PMID29915258
PMCPMC6006150
OpenAlexW2807992785

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.