ArticleNature communications2018
Structure determination from single molecule X-ray scattering with three photons per image.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Two datasets are better than one: method of double moments for 3D reconstruction in cryo-EM.Inverse problems · 2026Article
- Structure Determination from Single-Molecule X-ray Scattering Images Using Stochastic Gradient Ascent.Journal of chemical theory and computation · 2025Article
- Scalable 3D reconstruction for X-ray single particle imaging with online machine learning.Nature communications · 2025Article
- Bayesian electron density determination from sparse and noisy single-molecule X-ray scattering images.Science advances · 2024Article
- Article
- A workflow for single-particle structure determination via iterative phasing of rotational invariants in fluctuation X-ray scattering.Journal of applied crystallography · 2024Article
- Structure determination using high-order spatial correlations in single-particle X-ray scattering.IUCrJ · 2024Article
- Single-Molecule X-ray Scattering Used to Visualize the Conformation Distribution of Biological Molecules via Single-Object Scattering Sampling.International journal of molecular sciences · 2023Article
- Molecular size dependence on achievable resolution from XFEL single-particle 3D reconstruction.Structural dynamics (Melville, N.Y.) · 2023Article
- Article
- Structural studies of protein-nucleic acid complexes: A brief overview of the selected techniques.Computational and structural biotechnology journal · 2023Review
- Random conical tilt reconstruction without particle picking in cryo-electron microscopy.Acta crystallographica. Section A, Foundations and advances · 2022Article
- Super-resolution multi-reference alignment.Information and inference : a journal of the IMA · 2022Article
- Article
- Comparison of EMC and CM methods for orienting diffraction images in single-particle imaging experiments.IUCrJ · 2021Article
- Wilson statistics: derivation, generalization and applications to electron cryomicroscopy.Acta crystallographica. Section A, Foundations and advances · 2021Article
- An encryption-decryption framework to validating single-particle imaging.Scientific reports · 2021Article
- Bayesian Random Tomography of Particle Systems.Frontiers in molecular biosciences · 2021Article
- Reproducibility in the unfolding process of protein induced by an external electric field.Chemical science · 2020Article
- Structural Heterogeneity in Single Particle Imaging Using X-ray Lasers.The journal of physical chemistry letters · 2020Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scattering experiments with femtosecond high-intensity free-electron laser pulses provide a new route to macromolecular structure determination. While currently limited to nano-crystals or virus particles, the ultimate goal is scattering on single biomolecules. The main challenges in these experiments are the extremely low signal-to-noise ratio due to the very low expected photon count per scattering image, often well below 100, as well as the random orientation of the molecule in each shot. Here we present a de novo correlation-based approach and show that three coherently scattered photons per image suffice for structure determination. Using synthetic scattering data of a small protein, we demonstrate near-atomic resolution of 3.3 Å using 3.3 × 10
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