Evidence map›Paper›PMID 29915235›Full record

ArticleNature chemical biology2018

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides.

Vincent Wiebach, Andi Mainz, Mary-Ann J Siegert, Natalia A Jungmann, Guillaume Lesquame, Sophie Tirat, Assia Dreux-Zigha, Jozsef Aszodi, Dominique Le Beller, Roderich D Süssmuth

Abstract read
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In one paragraph

Article in Nature chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Exploring RiPP-derivedRSC chemical biology · 2026
    Article
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  5. Article
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  7. Structure, biosynthesis, and bioactivity of nostolysamides.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Promiscuity of lanthipeptide enzymes: new challenges and applications.World journal of microbiology & biotechnology · 2025
    Review
  12. Article
  13. Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.Angewandte Chemie (International ed. in English) · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vincent WiebachFaculty II - Department of Chemistry, Technische Universität Berlin, Berlin, Germany.
Andi MainzFaculty II - Department of Chemistry, Technische Universität Berlin, Berlin, Germany.
Mary-Ann J SiegertFaculty II - Department of Chemistry, Technische Universität Berlin, Berlin, Germany.
Natalia A JungmannFaculty II - Department of Chemistry, Technische Universität Berlin, Berlin, Germany.
Guillaume LesquameDeinobiotics, Grabels, France.
Sophie TiratICV-Institute Charles Viollette, Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral Côte d'Opale, Lille, France.
Assia Dreux-ZighaDeinobiotics, Grabels, France.
Jozsef AszodiDeinobiotics, Grabels, France.
Dominique Le BellerDeinobiotics, Grabels, France.
Roderich D SüssmuthFaculty II - Department of Chemistry, Technische Universität Berlin, Berlin, Germany. suessmuth@chem.tu-berlin.de.ORCID http://orcid.org/0000-0001-7027-2069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potent antibacterial lanthipeptide microvionin, isolated from a culture of Microbacterium arborescens, exhibits a new triamino-dicarboxylic acid moiety, termed avionin, and an unprecedented N-terminal guanidino fatty acid. We identified the corresponding biosynthetic gene cluster and reconstituted central steps of avionin biosynthesis in vitro. Genome mining and isolation of nocavionin from Nocardia terpenica revealed a widespread distribution of this lanthipeptide class, termed lipolanthines, which may be useful as future antimicrobial drugs.

Indexed as

Anti-Bacterial AgentsLipopeptidesMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsRibosomesAnti-Bacterial AgentsLipopeptides

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.