Trial reportNature communications2018
PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze.
Trial report in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Clinical Significance of Rhinoviruses and Progress Toward Vaccination.Allergy, asthma & immunology research · 2025Review
- Association between asthma and IgG levels specific for rhinovirus and respiratory syncytial virus antigens in children and adults.The journal of allergy and clinical immunology. Global · 2025Article
- Identification of common genes of rhinovirus single/double‑stranded RNA‑induced asthma deterioration by bioinformatics analysis.Experimental and therapeutic medicine · 2024Article
- Determinants of immunoglobulin G responses to respiratory syncytial virus and rhinovirus in children and adults.Frontiers in immunology · 2024Article
- Review
- Milk Allergen Micro-Array (MAMA) for Refined Detection of Cow's-Milk-Specific IgE Sensitization.Nutrients · 2023Article
- Importance, Applications and Features of Assays Measuring SARS-CoV-2 Neutralizing Antibodies.International journal of molecular sciences · 2023Review
- Article
- Identification of Epitopes on Rhinovirus 89 Capsid Proteins Capable of Inducing Neutralizing Antibodies.International journal of molecular sciences · 2022Article
- Viral Infection and Respiratory Exacerbation in Children: Results from a Local German Pediatric Exacerbation Cohort.Viruses · 2022Article
- Characterization of the antibody response to SARS-CoV-2 in a mildly affected pediatric population.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.Allergy · 2022Article
- Cumulative IgE-levels specific for respiratory allergens as biomarker to predict efficacy of anti-IgE-based treatment of severe asthma.Frontiers in immunology · 2022Article
- Multiprofessional perinatal care in a pregnant patient with acute respiratory distress syndrome due to COVID-19.BMC pregnancy and childbirth · 2021Article
- Article
- SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8Science immunology · 2021Article
- Article
- Dissociation of the respiratory syncytial virus F protein-specific human IgG, IgA and IgM response.Scientific reports · 2021Article
- Risk Factors Associated With Health Care Utilization in Preschool Recurrent Wheezers in a Tropical Environment.Frontiers in allergy · 2021Article
- Features of the Human Antibody Response against the Respiratory Syncytial Virus Surface Glycoprotein G.Vaccines · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerous RV types is a major challenge for the identification of the culprit virus types and for the improvement of virus type-specific treatment strategies. Here, we develop a chip containing 130 different micro-arrayed RV proteins and peptides and demonstrate in a cohort of 120 pre-school children, most of whom had been hospitalized due to acute wheeze, that it is possible to determine the culprit RV species with a minute blood sample by serology. Importantly, we identify RV-A and RV-C species as giving rise to most severe respiratory symptoms. Thus, we have generated a chip for the serological identification of RV-induced respiratory illness which should be useful for the rational development of preventive and therapeutic strategies targeting the most important RV types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.