Evidence map›Paper›PMID 29915154›Full record

ArticleMolecular and cellular biology2018

Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment.

Courtney J Fleenor, Tessa Arends, Hong Lei, Josefine Åhsberg, Kazuki Okuyama, Jacob Kuruvilla, Susana Cristobal, Jennifer L Rabe, Ahwan Pandey, Thomas Danhorn and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  3. iScience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Courtney J FleenorDepartment of Biomedical Sciences, National Jewish Health, Denver, Colorado, USA.
Tessa ArendsMolecular Biology Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Hong LeiDepartment of Biomedical Sciences, National Jewish Health, Denver, Colorado, USA.
Josefine ÅhsbergDepartment of Clinical and Experimental Medicine, Experimental Hematopoiesis Unit, Linköping University, Linköping, Sweden.
Kazuki OkuyamaDepartment of Clinical and Experimental Medicine, Experimental Hematopoiesis Unit, Linköping University, Linköping, Sweden.
Jacob KuruvillaDepartment of Clinical and Experimental Medicine, Experimental Hematopoiesis Unit, Linköping University, Linköping, Sweden.
Susana CristobalDepartment of Clinical and Experimental Medicine, Experimental Hematopoiesis Unit, Linköping University, Linköping, Sweden.
Jennifer L RabeMolecular Biology Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Ahwan PandeyLinda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Thomas DanhornIntegrated Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA.
Desiree StraignDepartment of Biomedical Sciences, National Jewish Health, Denver, Colorado, USA.
Joaquin M EspinosaLinda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Søren WarmingGenentech, Inc., South San Francisco, California, USA.
Eric M PietrasMolecular Biology Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Mikael SigvardssonDepartment of Clinical and Experimental Medicine, Experimental Hematopoiesis Unit, Linköping University, Linköping, Sweden.
James R HagmanDepartment of Biomedical Sciences, National Jewish Health, Denver, Colorado, USA hagmanj@njhealth.org.
University of Colorado Anschutz Medical Campus · USLinköping University · SENational Jewish Health · US

Funding

Stress- and Promoter-Specific Mechanisms of Transcritpional Activation by p53R01CA117907 · NCI · UNIVERSITY OF COLORADO DENVER · PI ESPINOSA, JOAQUIN M. · 2006 to 2022
$4.4M
Molecular Mechanisms of Immune ToleranceT32AI074491 · NIAID · NATIONAL JEWISH HEALTH · PI CAMBIER, JOHN C, PELANDA, ROBERTA · 2009 to 2023
$4.1M
Regulation of B Cell Development and Function by Zfp521R01AI098417 · NIAID · NATIONAL JEWISH HEALTH · PI HAGMAN, JAMES R. · 2012 to 2016
$2.0M
Regulation of B Cell Identity and Lineage ProgressionR01AI081878 · NIAID · NATIONAL JEWISH HEALTH · PI HAGMAN, JAMES R. · 2010 to 2014
$1.9M
Pro-inflammatory cytokines in hematopoietic stem cell functionK01DK098315 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2014 to 2018
$691k
Regulation of V(D)J Recombination by Arginine MethylationR21AI115696 · NIAID · NATIONAL JEWISH HEALTH · PI HAGMAN, JAMES R. · 2015 to 2016
$436k
Role of RNA splicing factor U2AF1 in regulating hematopoietic stem cell inflammation responses.F31HL138754 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI RABE, JENNIFER L · 2017 to 2018
$60k
NCI NIH HHS R01 CA117907NHLBI NIH HHS F31 HL138754NIAID NIH HHS R01 AI081878NIAID NIH HHS R01 AI098417NIAID NIH HHS R21 AI115696NIAID NIH HHS T32 AI074491NIDDK NIH HHS K01 DK098315
6 · The paper itself

Abstract

Zinc finger protein 521 (ZFP521), a DNA-binding protein containing 30 Krüppel-like zinc fingers, has been implicated in the differentiation of multiple cell types, including hematopoietic stem and progenitor cells (HSPC) and B lymphocytes. Here, we report a novel role for ZFP521 in regulating the earliest stages of hematopoiesis and lymphoid cell development via a cell-extrinsic mechanism. Mice with inactivated

Indexed as

AnimalsB-LymphocytesCytokinesHematopoiesisHematopoietic Stem CellsLymphopoiesisMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMyelopoiesisProtein BindingStem Cell NicheT-LymphocytesTranscription FactorsCytokinesEvi3 protein, mouseTranscription Factorsbone marrow microenvironmenthematopoietic progenitorshematopoietic stem celllymphopoiesisZFP521/ZNF521

Identifiers

PMID29915154
PMCPMC6094055
OpenAlexW2808788067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.