ArticleStroke2018
Open access · hybridAbstract read
In one paragraph
Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.Journal of the neurological sciences · 2019Pooled it
- Influences of genetic variants on stroke recovery: a meta-analysis of the 31,895 cases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- Advancing stroke genetics in Hawai'i and the Pacific Islands.Frontiers in stroke · 2023Article
- Intracerebral Hemorrhage Genetics.Genes · 2022Review
- Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage.International journal of molecular sciences · 2022Review
- Genetics of common cerebral small vessel disease.Nature reviews. Neurology · 2022Review
- Genetics of Spontaneous Intracerebral Hemorrhage: Risk and Outcome.Frontiers in neuroscience · 2022Review
- Identification of lncRNA-mRNA regulatory network associated with isolated systolic hypertension and atherosclerotic cerebral infarction.Annals of translational medicine · 2021Article
- Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset.Neurocritical care · 2021Article
- Rare Missense Functional Variants atNeurology · 2021Article
- Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke.Nature reviews. Neurology · 2020Review
- Genetic Variation and Response to Neurocritical Illness: a Powerful Approach to Identify Novel Pathophysiological Mechanisms and Therapeutic Targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Genetic underpinnings of recovery after stroke: an opportunity for gene discovery, risk stratification, and precision medicine.Genome medicine · 2019Article
- Association of angiotensin-converting enzyme G2350A gene polymorphisms with hypertension among patients with intracerebral haemorrhage.Journal of Taibah University Medical Sciences · 2019Article
- The Comorbidities Coma Scale (CoCoS): Psychometric Properties and Clinical Usefulness in Patients With Disorders of Consciousness.Frontiers in neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 18 institutions in 4 countries.
Sandro MariniFrom the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.).
William J DevanFrom the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.).
Farid RadmaneshFrom the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.).
Laura MiyaresMassachusetts General Hospital, Boston; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., C.M., K.N.S., G.J.F.).
Timothy PoterbaAnalytic and Translational Genetics Unit (T.P.).
Björn M HansenDepartment of Neurology and Rehabilitation, Skåne University Hospital, Lund, Sweden (B.M.H., B.N., A.L.).
Bo NorrvingDepartment of Neurology and Rehabilitation, Skåne University Hospital, Lund, Sweden (B.M.H., B.N., A.L.).
Jordi Jimenez-CondeDepartment of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.).
Eva Giralt-SteinhauerDepartment of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.).
Roberto ElosuaDepartment of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.).
Elisa Cuadrado-GodiaDepartment of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.).
Carolina SorianoDepartment of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.).
Jaume RoquerDepartment of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.).
Christina E KourkoulisFrom the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.).
Alison M AyresUniversitat Autónoma de Barcelona, Spain; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA (A.M.A., K.S., S.M.G.).
Kristin SchwabUniversitat Autónoma de Barcelona, Spain; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA (A.M.A., K.S., S.M.G.).
David L TirschwellStroke Center, Harborview Medical Center, University of Washington, Seattle (D.L.T.).
Magdy SelimStroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (M.S.).
Devin L BrownStroke Program, Department of Neurology, University of Michigan, Ann Arbor (D.L.B.).
Scott L SillimanDepartment of Neurology, University of Florida College of Medicine, Jacksonville (S.L.S.).
Bradford B WorrallDepartment of Neurology and Public Health Sciences, University of Virginia Health System, Charlottesville (B.B.W.).
James F MeschiaDepartment of Neurology, Mayo Clinic, Jacksonville, FL (J.F.M.).
Chelsea S KidwellDepartment of Neurology, University of Arizona, Tucson (C.S.K.).
Joan MontanerNeurovascular Research Laboratory and Neurovascular Unit, Institut de Recerca, Hospital Vall d'Hebron (J.M., I.F.-C., P.D.).
Israel Fernandez-CadenasNeurovascular Research Laboratory and Neurovascular Unit, Institut de Recerca, Hospital Vall d'Hebron (J.M., I.F.-C., P.D.).
Pilar DelgadoNeurovascular Research Laboratory and Neurovascular Unit, Institut de Recerca, Hospital Vall d'Hebron (J.M., I.F.-C., P.D.).
Steven M GreenbergUniversitat Autónoma de Barcelona, Spain; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA (A.M.A., K.S., S.M.G.).
Arne LindgrenDepartment of Neurology and Rehabilitation, Skåne University Hospital, Lund, Sweden (B.M.H., B.N., A.L.).
Charles MatoukMassachusetts General Hospital, Boston; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., C.M., K.N.S., G.J.F.).
Kevin N ShethMassachusetts General Hospital, Boston; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., C.M., K.N.S., G.J.F.).
Daniel WooDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, OH (D.W.).
Christopher D AndersonFrom the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.).
Jonathan RosandFrom the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.).
Guido J FalconeMassachusetts General Hospital, Boston; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., C.M., K.N.S., G.J.F.) guido.falcone@yale.edu.
International Stroke Genetics Consortium
Center for Genomic Science · ITYale University · USC3J Therapeutics (United States) · USVall d'Hebron Institut de Recerca · ESHospital del Mar Research Institute · ESMassachusetts General Hospital · USSkåne University Hospital · SEBeth Israel Deaconess Medical Center · USFlorida College · USHarborview Medical Center · USHospital Del Mar · ESLund University · SEMayo Clinic in Florida · USMichigan Medicine · USUniversitat Autònoma de Barcelona · ESUniversity of Arizona · USUniversity of Cincinnati Medical Center · USUniversity of Virginia Health System · US
Funding
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9MEthnic/Racial Variation in Intracerebral Hemorrhage (ERICH)U01NS069763 · NINDS · UNIVERSITY OF CINCINNATI · PI ANDERSON, CHRISTOPHER DAVID, DEMEL, STACIE · 2010 to 2024
$34.2MGenetic&Environment Risk Factors for Hemorrhagic StrokeR01NS036695 · NINDS · UNIVERSITY OF CINCINNATI · PI WOO, DANIEL · 1997 to 2012
$14.1MRecurrent Hemorrhagic Stroke in Minority PopulationsR01NS093870 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI JONATHAN ROSAND, Amytis Towfighi · 2016 to 2026
$12.3MUsing genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3MGenetic and Environmental Risk Factors for Hemorrhagic StrokeU01NS036695 · NINDS · UNIVERSITY OF CINCINNATI · PI ROSAND, JONATHAN, WOO, DANIEL · 2016 to 2020
$7.0MGene Discovery for Warfarin-Related Intracerebral HemorrhageR01NS059727 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROSAND, JONATHAN · 2008 to 2012
$4.2MSequencing Annotation and Functional Analysis in Risk of Intracerebral HemorrhageR01NS103924 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2018 to 2022
$3.4MGenetic Analyses of Lipids in Cerebral Hemorrhage and Small Vessel DiseaseK23NS086873 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2014 to 2018
$951kNHLBI NIH HHS R01 HL127564NIA NIH HHS P30 AG021342NINDS NIH HHS K23 NS086873NINDS NIH HHS R01 NS036695NINDS NIH HHS R01 NS059727NINDS NIH HHS R01 NS093870NINDS NIH HHS R01 NS103924NINDS NIH HHS U01 NS036695NINDS NIH HHS U01 NS069763
Abstract
background and purposeHematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH.
methodsWe conducted a 2-stage (discovery and replication) case-only genome-wide association study in patients with ICH of European ancestry. We utilized the admission head computed tomography to calculate hematoma volume via semiautomated computer-assisted technique. After quality control and imputation, 7 million genetic variants were available for association testing with ICH volume, which was performed separately in lobar and nonlobar ICH cases using linear regression. Signals with
resultsThe discovery phase included 394 ICH cases (228 lobar and 166 nonlobar) and identified 2 susceptibility loci: a genomic region on 22q13 encompassing
conclusionsWe identified
Indexed as
Chromosomes, Human, Pair 17AgedAged, 80 and overCerebral HemorrhageFemaleGenome-Wide Association StudyGenotypeHematomaHumansMaleMiddle AgedPolymorphism, Single Nucleotidecerebral hemorrhagegeneticsgenome-wide association studyhumansneuroimaging
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.