ArticleProceedings of the National Academy of Sciences of the United States of America2018
ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Selective autophagy of intracellular organelles: recent research advances.Theranostics · 2021Pooled it
- Atg39-dependent nucleophagy and Atg40-dependent ER-phagy require the Apq12/Brr6/Brl1 complex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Coupling of cargo to the autophagy receptor is a critical step in ER-phagy.Science advances · 2026Article
- COST1 stimulates RHD3 GTPase activity to maintain ER morphology and plant growth inScience advances · 2026Article
- ER remodelling is a feature of ageing and depends on ER-phagy.Nature cell biology · 2026Article
- A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope.Nature cell biology · 2025Article
- PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions.The Journal of cell biology · 2024Article
- A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope.bioRxiv : the preprint server for biology · 2024Article
- Different ER-plasma membrane tethers play opposing roles in autophagy of the cortical ER.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies.International journal of biological sciences · 2024Review
- Autophagy of the ER: the secretome finds the lysosome.The FEBS journal · 2023Review
- The ortholog of human REEP1-4 is required for autophagosomal enclosure of ER-phagy/nucleophagy cargos in fission yeast.PLoS biology · 2023Article
- A conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast.Nature communications · 2023Article
- ER-Phagy: Quality and Quantity Control of the Endoplasmic Reticulum by Autophagy.Cold Spring Harbor perspectives in biology · 2023Review
- ER-phagy: selective autophagy of the endoplasmic reticulum.EMBO reports · 2022Review
- ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum.Physiological reviews · 2022Review
- ER remodeling via ER-phagy.Molecular cell · 2022Review
- ER-phagy requires the assembly of actin at sites of contact between the cortical ER and endocytic pits.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Programmed cortical ER collapse drives selective ER degradation and inheritance in yeast meiosis.The Journal of cell biology · 2021Article
- Advances in ER-Phagy and Its Diseases Relevance.Cells · 2021Review
Corrections and comments
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Authors and funding
5 authors.
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Abstract
The endoplasmic reticulum (ER) forms a contiguous network of tubules and sheets that is predominantly associated with the cell cortex in yeast. Upon treatment with rapamycin, the ER undergoes degradation by selective autophagy. This process, termed ER-phagy, requires Atg40, a selective autophagy receptor that localizes to the cortical ER. Here we report that ER-phagy also requires Lnp1, an ER membrane protein that normally resides at the three-way junctions of the ER network, where it serves to stabilize the network as it is continually remodeled. Rapamycin treatment increases the expression of Atg40, driving ER domains marked by Atg40 puncta to associate with Atg11, a scaffold protein needed to form autophagosomes. Although Atg40 largely localizes to the cortical ER, the autophagy machinery resides in the cell interior. The localization of Atg40 to sites of autophagosome formation is blocked in an
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.