ArticleProceedings of the National Academy of Sciences of the United States of America2018
Accelerating pathway evolution by increasing the gene dosage of chromosomal segments.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
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- Rewiring Aromatic Compound Consumption: Chromosomal Amplification and Evolution of a Foreign Pathway inACS synthetic biology · 2025Article
- Laboratory evolution inApplied and environmental microbiology · 2025Article
- Metabolic engineering ofMetabolic engineering communications · 2024Article
- Carbon-wise utilization of lignin-related compounds by synergistically employing anaerobic and aerobic bacteria.Biotechnology for biofuels and bioproducts · 2024Article
- A keyApplied and environmental microbiology · 2023Article
- Testing for the fitness benefits of natural transformation during community-embedded evolution.Microbiology (Reading, England) · 2023Article
- Abiotic selection of microbial genome size in the global ocean.Nature communications · 2023Article
- Engineering cell morphology by CRISPR interference in Acinetobacter baylyi ADP1.Microbial biotechnology · 2022Article
- The Catabolic System of Acetovanillone and Acetosyringone inApplied and environmental microbiology · 2022Article
- Regulation of l- and d-Aspartate Transport and Metabolism in Acinetobacter baylyi ADP1.Applied and environmental microbiology · 2022Article
- Transcription factor retention through multiple polyploidization steps in wheat.G3 (Bethesda, Md.) · 2022Article
- An in vivo gene amplification system for high level expression in Saccharomyces cerevisiae.Nature communications · 2022Article
- Cytochromes P450 in the biocatalytic valorization of lignin.Current opinion in biotechnology · 2022Review
- Characterization of Highly Ferulate-Tolerant Acinetobacter baylyi ADP1 Isolates by a Rapid Reverse Engineering Method.Applied and environmental microbiology · 2022Article
- Thiols Act as Methyl Traps in the Biocatalytic Demethylation of Guaiacol Derivatives.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021Article
- Thiols Act as Methyl Traps in the Biocatalytic Demethylation of Guaiacol Derivatives.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental evolution is a critical tool in many disciplines, including metabolic engineering and synthetic biology. However, current methods rely on the chance occurrence of a key step that can dramatically accelerate evolution in natural systems, namely increased gene dosage. Our studies sought to induce the targeted amplification of chromosomal segments to facilitate rapid evolution. Since increased gene dosage confers novel phenotypes and genetic redundancy, we developed a method, Evolution by Amplification and Synthetic Biology (EASy), to create tandem arrays of chromosomal regions. In
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