ArticleProceedings of the National Academy of Sciences of the United States of America2018
Changes in white matter in mice resulting from low-frequency brain stimulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Effects of Hyperdirect Pathway Theta Burst Transcranial Magnetic Stimulation on Inhibitory Control, Craving, and Smoking in Adults With Nicotine Dependence: A Double-Blind, Randomized Crossover Trial.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Trial
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- Early life adversity and adult attention-deficit/hyperactivity disorder (ADHD): Pathways to persistence and adult susceptibility.Neuroscience and biobehavioral reviews · 2025Review
- Reorganization of dopamine circuitry in the anterior corpus callosum between early adolescence and adulthood in the mouse.The European journal of neuroscience · 2024Article
- Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum.Brain structure & function · 2023Article
- Article
- Beyond Infant's Looking: The Neural Basis for Infant Prediction Errors.Perspectives on psychological science : a journal of the Association for Psychological Science · 2023Review
- How understanding and strengthening brain networks can contribute to elementary education.Frontiers in public health · 2023Review
- Effortless training of attention and self-control: mechanisms and applications.Trends in cognitive sciences · 2022Review
- Decision Making as a Learned Skill in Mice and Humans.Frontiers in neuroscience · 2022Review
- A physical perspective to understand myelin II: The physical origin of myelin development.Frontiers in neuroscience · 2022Article
- Endogenous theta stimulation during meditation predicts reduced opioid dosing following treatment with Mindfulness-Oriented Recovery Enhancement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination.Life (Basel, Switzerland) · 2021Review
- The thermodynamics of cognition: A mathematical treatment.Computational and structural biotechnology journal · 2021Article
- Interventions and Manipulations of Interoception.Trends in neurosciences · 2021Review
- Nalfurafine reduces neuroinflammation and drives remyelination in models of CNS demyelinating disease.Clinical & translational immunology · 2021Article
- Can Enhancing Neuronal Activity Improve Myelin Repair in Multiple Sclerosis?Frontiers in cellular neuroscience · 2021Review
- The thermodynamic brain and the evolution of intellect: the role of mental energy.Cognitive neurodynamics · 2020Review
- Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex.Neural development · 2020Article
- White matter structure and myelin-related gene expression alterations with experience in adult rats.Progress in neurobiology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports have begun to elucidate mechanisms by which learning and experience produce white matter changes in the brain. We previously reported changes in white matter surrounding the anterior cingulate cortex in humans after 2-4 weeks of meditation training. We further found that low-frequency optogenetic stimulation of the anterior cingulate in mice increased time spent in the light in a light/dark box paradigm, suggesting decreased anxiety similar to what is observed following meditation training. Here, we investigated the impact of this stimulation at the cellular level. We found that laser stimulation in the range of 1-8 Hz results in changes to subcortical white matter projection fibers in the corpus callosum. Specifically, stimulation resulted in increased oligodendrocyte proliferation, accompanied by a decrease in the g-ratio within the corpus callosum underlying the anterior cingulate cortex. These results suggest that low-frequency stimulation can result in activity-dependent remodeling of myelin, giving rise to enhanced connectivity and altered behavior.
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