Evidence map›Paper›PMID 29914980›Full record

ArticleDisease models & mechanisms2018

Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation.

Laura E Schultz, Jeffrey A Haltom, Maira P Almeida, Wesley A Wierson, Staci L Solin, Trevor J Weiss, Jordan A Helmer, Elizabeth J Sandquist, Heather R Shive, Maura McGrail

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Cancers · 2022
    Article
  8. Zebrafish Models of Paediatric Brain Tumours.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Article
  11. Cre/eLife · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Laura E SchultzDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Jeffrey A HaltomDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Maira P AlmeidaDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Wesley A WiersonDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Staci L SolinDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Trevor J WeissDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Jordan A HelmerDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Elizabeth J SandquistDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Heather R ShiveDepartment of Population Health and Pathobiology, North Carolina State University, Raleigh, NC 27607, USA.
Maura McGrailDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA mmcgrail@iastate.edu.ORCID 0000-0001-9308-6189
Iowa State University · USNorth Carolina State University · US

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
In vivo model of microglia inflammasome signaling in neuroinflammationR24OD020166 · OD · IOWA STATE UNIVERSITY · PI CLARK, KARL J, EKKER, STEPHEN CARL · 2016 to 2023
$7.1M
Identification of genetic collaborators in cancer with a brca2-mutant zebrafish modelK01OD021419 · OD · OHIO STATE UNIVERSITY · PI SHIVE, HEATHER R. · 2016 to 2021
$731k
NIGMS NIH HHS P20 GM103638NIH HHS R24 OD020166
6 · The paper itself

Abstract

In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish

Indexed as

Epigenesis, GeneticAnimalsBrain NeoplasmsCell ProliferationCell SurvivalHistone Deacetylase 1Neural Stem CellsRetinoblastoma-Binding Protein 4Retinoblastoma ProteinZebrafishZebrafish ProteinsHDAC1 protein, zebrafishHistone Deacetylase 1Retinoblastoma-Binding Protein 4Retinoblastoma ProteinZebrafish ProteinsCRISPR somatic targetingEpigenetic regulatorsHdac1Neural progenitorRB1 embryonal oligoneural brain tumorRbbp4Zebrafish

Identifiers

PMID29914980
PMCPMC6031359
OpenAlexW2808286397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.