ArticleAntimicrobial agents and chemotherapy2018
Efficacy and Pharmacokinetics Evaluation of a Single Oral Dose of Afoxolaner against Sarcoptes scabiei in the Porcine Scabies Model for Human Infestation.
Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A rapid evidence assessment of the potential risk to the environment presented by active ingredients in the UK's most commonly sold companion animal parasiticides.Environmental science and pollution research international · 2022Pooled it
- Field efficacy assessment of a combination of afoxolaner, moxidectin and pyrantel pamoate to treat dogs naturally infested with Sarcoptes scabiei.Parasite (Paris, France) · 2026Article
- Expression profiles of itch markers during scabies infection in a porcine scabies model.PLoS neglected tropical diseases · 2025Article
- Scabies.Nature reviews. Disease primers · 2024Review
- Acute Glomerulonephritis Following Systemic Scabies in Two Brothers.Children (Basel, Switzerland) · 2024Article
- Ivermectin therapy for young children with scabies infection: a multicentre phase 2 non-randomized trial.The Lancet regional health. Western Pacific · 2024Article
- Evaluation of the scabicidal effect of a single dose of fluralaner in a rabbit model of crusted scabies.Parasitology research · 2023Article
- Can Ivermectin kill Sarcoptes scabiei during the molting process?PLoS neglected tropical diseases · 2023Article
- Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife.International journal for parasitology. Drugs and drug resistance · 2023Review
- Severe Scabies: A French Multi-centre Study Involving 95 Patients with Crusted and Profuse Disease and Review of the Literature.Acta dermato-venereologica · 2023Review
- Oral Albendazole as an Alternative Treatment for Moderate Crusted Scabies Along with 5% Permethrin and 5% Salicylic Acid.International medical case reports journal · 2022Article
- Ivermectin Plasma Concentration in Iberian Ibex (Frontiers in veterinary science · 2022Article
- Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use.Parasites & vectors · 2021Article
- Assessment of Knowledge and Fear of Scabies in a Saudi Population.Journal of multidisciplinary healthcare · 2021Article
- Recent advances in understanding and treating scabies.Faculty reviews · 2021Review
- Itch in Scabies-What Do We Know?Frontiers in medicine · 2021Review
- The Management of Scabies in the 21st Century: Past, Advances and Potentials.Acta dermato-venereologica · 2020Review
- Article
- Afoxolaner as a Treatment for a NovelFrontiers in veterinary science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scabies is a major and potentially growing public health problem worldwide with an unmet need for acaricidal agents with greater efficacy and improved pharmacological properties for its treatment. The objective of the present study was to assess the efficacy and describe the pharmacokinetics profile of a novel acaricide, afoxolaner (AFX), in a relevant experimental porcine model. Twelve pigs were experimentally infested and either treated with 2.5 mg/kg single dose oral AFX (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.