Evidence map›Paper›PMID 29914945›Full record

ArticleAntimicrobial agents and chemotherapy2018

Pharmacological Inhibition of the Vacuolar ATPase in Bloodstream-Form Trypanosoma brucei Rescues Genetic Knockdown of Mitochondrial Gene Expression.

Claudia Schaffner-Barbero, Migla Miskinyte, Jaspreet Singh Grewal, Achim Schnaufer

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Claudia Schaffner-Barbero *Institute of Immunology & Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Migla Miskinyte *Institute of Immunology & Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Jaspreet Singh GrewalDepartment of Biology, Centre for Immunology and Infection, University of York, York, United Kingdom.
Achim SchnauferInstitute of Immunology & Infection Research, University of Edinburgh, Edinburgh, United Kingdom achim.schnaufer@ed.ac.uk.ORCID 0000-0003-2132-5560
Centre for Immunity, Infection and Evolution · GBUniversity of York · GB

Funding

Medical Research Council MR/K019384Medical Research Council MR/L019701/1
6 · The paper itself

Abstract

Trypanosomatid parasites cause diseases in humans and livestock. It was reported that partial inhibition of the vacuolar ATPase (V-ATPase) affects the dependence of

Indexed as

AnimalsDNA, KinetoplastGene ExpressionGene Knockdown TechniquesGenes, MitochondrialGenome, MitochondrialHumansMitochondriaPhenanthridinesProtozoan ProteinsTrypanocidal AgentsTrypanosoma brucei bruceiVacuolar Proton-Translocating ATPasesDNA, Kinetoplastisometamidium chloridePhenanthridinesProtozoan ProteinsTrypanocidal AgentsVacuolar Proton-Translocating ATPasesbafilomycinF1Fo-ATPasekDNAkinetoplastmitochondriaRNA editingTrypanosomavacuolesV-ATPase

Identifiers

PMID29914945
PMCPMC6125517
OpenAlexW2807792118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.