Evidence map›Paper›PMID 29914944›Full record

ArticleAntimicrobial agents and chemotherapy2018

Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene.

Christopher E Wozniak, Zhenjian Lin, Eric W Schmidt, Kelly T Hughes, Theodore G Liou

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. A coevolution experiment betweenMicrobiology (Reading, England) · 2023
    Article
  7. Mining Fatty Acid Biosynthesis for New Antimicrobials.Annual review of microbiology · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. An in situ high-throughput screen identifies inhibitors of intracellularProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  13. Journal of natural products · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christopher E WozniakDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Zhenjian LinCollege of Pharmacy, Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.
Eric W SchmidtCollege of Pharmacy, Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.
Kelly T HughesDepartment of Biology, University of Utah, Salt Lake City, Utah, USA.
Theodore G LiouDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA ted.liou@utah.edu.ORCID 0000-0003-0121-4847
University of Utah · US

Funding

Coupling gene regulation to flagellar morphogenesisR01GM056141 · NIGMS · UNIVERSITY OF WASHINGTON · PI HUGHES, KELLY T · 1998 to 2023
$8.3M
Symbiosis and Chemical Diversity GenerationR35GM122521 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2017 to 2021
$2.9M
Explanatory models of CF Survival, Infection and Intermediate Clinical OutcomesR01HL125520 · NHLBI · UNIVERSITY OF UTAH · PI LIOU, THEODORE GEH-LU · 2015 to 2018
$1.4M
NHLBI NIH HHS R01 HL125520NIGMS NIH HHS R01 GM056141NIGMS NIH HHS R35 GM122521
6 · The paper itself

Abstract

Microbes encode many uncharacterized gene clusters that may produce antibiotics and other bioactive small molecules. Methods for activating these genes are needed to explore their biosynthetic potential. A transposon containing an inducible promoter was randomly inserted into the genome of the soil bacterium

Indexed as

Acetyl-CoA CarboxylaseAnti-Bacterial AgentsBacterial ProteinsBurkholderiaFatty AcidsGene Expression Regulation, BacterialPolyketidesPromoter Regions, GeneticAcetyl-CoA CarboxylaseAnti-Bacterial AgentsBacterial ProteinsFatty AcidsPolyketidesthailandamide Aacetyl-CoA carboxylaseantimicrobialBurkholderia thailandensisglobal regulatorpolyketide

Identifiers

PMID29914944
PMCPMC6125523
OpenAlexW2808256516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.