Evidence map›Paper›PMID 29914927›Full record

ArticleInfection and immunity2018

Regulation of the Peptidoglycan Amidase PGLYRP2 in Epithelial Cells by Interleukin-36γ.

Glen M Scholz, Jacqueline E Heath, Jiamin Aw, Eric C Reynolds

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Epithelial cells release IL-36α in extracellular vesicles following mechanical damage.Biochemical and biophysical research communications · 2022
    Article
  4. IL-1 Superfamily Members and Periodontal Diseases.Journal of dental research · 2020
    Review
  5. Article
  6. Article
  7. New Insights inFrontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Glen M Scholz *Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.
Jacqueline E Heath *Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.
Jiamin AwOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.
Eric C ReynoldsOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia e.reynolds@unimelb.edu.au.
University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-36 (IL-36) cytokines are important regulators of mucosal homeostasis and inflammation. We have previously established that oral epithelial cells upregulate IL-36γ expression in response to the bacterial pathogen

Indexed as

Carrier ProteinsCells, CulturedEpithelial CellsGene ExpressionGene Expression RegulationHomeostasisHumansInflammationInterleukin-1Interleukin-17Interleukin-1 Receptor-Associated KinasesInterleukin-22InterleukinsMouth Mucosap38 Mitogen-Activated Protein KinasesPeptidoglycanCarrier ProteinsIL17A protein, humanIL36G protein, humanInterleukin-1Interleukin-17Interleukin-1 Receptor-Associated KinasesInterleukin-22InterleukinsIRAK1 protein, humanp38 Mitogen-Activated Protein KinasesPeptidoglycanpeptidoglycan recognition proteinantimicrobialEGFepithelial cellsIL-36peptidoglycan recognition proteinPorphyromonas gingivalis

Identifiers

PMID29914927
PMCPMC6105881
OpenAlexW2893599355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.