Evidence map›Paper›PMID 29914721›Full record

ReviewTrends in neurosciences2018

Peripheral and Central Nutrient Sensing Underlying Appetite Regulation.

Vineet Augustine, Sertan Kutal Gokce, Yuki Oka

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. The intra-oral variation of salivary ions.Clinical oral investigations · 2025
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  17. Neural populations for maintaining body fluid balance.Current opinion in neurobiology · 2019
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vineet AugustineDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Sertan Kutal GokceDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Yuki OkaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address: yoka@caltech.edu.

Funding

Deep brain photoacoustic tomography at single-neuron resolution using arrays of photonic emitters and high-frequency ultrasound transducersU01NS099717 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROUKES, MICHAEL L, SHEPARD, KENNETH L · 2016 to 2018
$3.0M
Neural circuits underlying thirst and satiety regulationR01NS109997 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI OKA, YUKI · 2018 to 2022
$1.9M
Genetic dissection of the neural circuits regulating appetiteR56MH113030 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI OKA, YUKI · 2017 to 2018
$825k
NIMH NIH HHS R56 MH113030NINDS NIH HHS R01 NS109997NINDS NIH HHS U01 NS099717
6 · The paper itself

Abstract

The precise regulation of fluid and energy homeostasis is essential for survival. It is well appreciated that ingestive behaviors are tightly regulated by both peripheral sensory inputs and central appetite signals. With recent neurogenetic technologies, considerable progress has been made in our understanding of basic taste qualities, the molecular and/or cellular basis of taste sensing, and the central circuits for thirst and hunger. In this review, we first highlight the functional similarities and differences between mammalian and invertebrate taste processing. We then discuss how central thirst and hunger signals interact with peripheral sensory signals to regulate ingestive behaviors. We finally indicate some of the directions for future research.

Indexed as

AnimalsAppetite RegulationBrainHumansPerceptionSensationSensory Receptor Cellshungersensory valencetastethirsttop-down regulation

Identifiers

PMID29914721
PMCPMC6064385

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.