Evidence map›Paper›PMID 29914664›Full record

ArticleNutrition research (New York, N.Y.)2018

Higher dietary inflammation is associated with increased odds of depression independent of Framingham Risk Score in the National Health and Nutrition Examination Survey.

Dana Jorgensen, Gretchen E White, Akira Sekikawa, Peter Gianaros

Abstract read
In one paragraph

Article in Nutrition research (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dana JorgensenDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health. Electronic address: Drj19@pitt.edu.
Gretchen E WhiteDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health.
Akira SekikawaDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health.
Peter GianarosDepartment of Psychology, University of Pittsburgh.

Funding

Cardiovascular Epidemiology Training ProgramT32HL083825 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AKIRA SEKIKAWA · 2008 to 2026
$6.1M
Neurobiological pathways linking stress and emotion to atherosclerosisR01HL089850 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GIANAROS, PETER J · 2008 to 2016
$4.7M
NHLBI NIH HHS R01 HL089850NHLBI NIH HHS T32 HL083825
6 · The paper itself

Abstract

Cardiovascular disease (CVD) may increase depression risk. Risk for future CVD, which can be estimated by the Framingham Risk Score (FRS), and depression risk are both linked to systemic inflammation. Dietary consumption of proinflammatory food can be measured using the Dietary Inflammatory Index (DII) score. We examined the potential impact of DII on depression and whether this effect is independent of FRS. We hypothesized that (1) both FRS and DII would be associated with depression (Patient Health Questionnaire-9 ≥ 10) and (2) associations between DII and depressive symptoms (continuous) would be mediated by FRS. Data were included from adults without CVD who were participants of the 2007-2012 National Health and Nutrition Examination Survey (n = 11 624). Using logistic regression, we tested cross-sectional associations of FRS, DII (adjusting for FRS), and joint effects of FRS and DII with depression. Finally, using the Sobel method, we tested whether FRS mediates the relationship between DII and depressive symptoms. Individuals with FRS or DII scores in the top 2 quartiles had higher odds of depressive symptoms than those in the bottom quartile. The association of DII with depressive symptoms remained after FRS adjustment. The joint effects of elevated DII and FRS were additive. There was no evidence for mediation by FRS between DII and depressive symptoms. Thus, higher DII remained associated with increased odds of depressive symptoms net CVD risk. Collectively, the joint effects of CVD risk and DII indicate that a proinflammatory diet could add to risk for depressive symptoms even in those with a high FRS.

Indexed as

Feeding BehaviorAdultCardiovascular DiseasesCross-Sectional StudiesDepressionDepressive DisorderDietFemaleHumansInflammationLogistic ModelsMaleNutrition SurveysRisk FactorsSurveys and QuestionnairesCardiovascular disease riskDepressionDietary inflammationSystemic inflammation

Identifiers

PMID29914664
PMCPMC6011232

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.