Evidence map›Paper›PMID 29914582›Full record

ArticleEpidemiology and infection2018

Importance of case age in the purported association between phylogenetics and hemolytic uremic syndrome in Escherichia coli O157:H7 infections.

G A M Tarr, S Shringi, H N Oltean, J Mayer, P Rabinowitz, J Wakefield, P I Tarr, T E Besser, A I Phipps

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Prevalence and Implications of Shiga Toxin-ProducingPathogens (Basel, Switzerland) · 2022
    Review
  2. Antibiotic resistance and phylogenetic profiling ofCurrent research in microbial sciences · 2022
    Article
  3. Toxins · 2021
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

G A M TarrDepartment of Pediatrics,University of Calgary Cumming School of Medicine,Calgary,Alberta,CA.ORCID 0000-0001-7372-1034
S ShringiVeterinary Microbiology and Pathology,Washington State University,Pullman,Washington,USA.
H N OlteanWashington State Department of Health,Shoreline, Washington,USA.
J MayerDepartment of Epidemiology,University of Washington,Seattle,Washington,USA.
P RabinowitzDepartment of Environmental and Occupational Health Sciences and Center for One Health Research,University of Washington,Seattle,Washington,USA.
J WakefieldDepartments of Biostatistics and Statistics,University of Washington,Seattle,Washington,USA.
P I TarrDepartment of Pediatrics,Washington University in St. Louis School of Medicine,St. Louis,Missouri,USA.
T E BesserVeterinary Microbiology and Pathology,Washington State University,Pullman,Washington,USA.
A I PhippsDepartment of Epidemiology,University of Washington,Seattle,Washington,USA.
University of Washington · USWashington State University · USUniversity of Calgary · CAWashington State Department of Health · USWashington University in St. Louis · US

Funding

Biostatistics, Epidemiologic & Bioinformatic Training in Environmental HealthT32ES015459 · NIEHS · UNIVERSITY OF WASHINGTON · PI June T. Spector · 2009 to 2026
$10.6M
Escherichia coli O157 Phylogeny: Implications for Virulence and Disease DistributionF31AI126834 · NIAID · UNIVERSITY OF WASHINGTON · PI TARR, GILLIAN · 2017 to 2017
$32k
NIAID NIH HHS F31 AI126834NIEHS NIH HHS T32 ES015459
6 · The paper itself

Abstract

Escherichia coli O157:H7 is the largest cause of hemolytic uremic syndrome (HUS). Previous studies proposed that HUS risk varies across the E. coli O157:H7 phylogenetic tree (hypervirulent clade 8), but the role of age in the association is unknown. We determined phylogenetic lineage of E. coli O157:H7 isolates from 1160 culture-confirmed E. coli O157:H7 cases reported in Washington State, 2004-2015. Using generalised estimating equations, we tested the association between phylogenetic lineage and HUS. Age was evaluated as an effect modifier. Among 1082 E. coli O157:H7 cases with both phylogenetic lineage and HUS status (HUS n = 76), stratified analysis suggested effect modification by age. Lineages IIa and IIb, relative to Ib, did not appear associated with HUS in children 0-9-years-old. For cases 10-59-years-old, lineages IIa and IIb appeared to confer increased risk of HUS, relative to lineage Ib. The association reversed in ⩾60-year-olds. Results were similar for clade 8. Phylogenetic lineage appears to be associated with HUS risk only among those ⩾10-years-old. Among children <10, the age group most frequently affected, lineage does not explain progression to HUS. However, lineage frequency varied across age groups, suggesting differences in exposure and/or early disease manifestation.

Indexed as

AdolescentAdultAge FactorsChildChild, PreschoolEscherichia coli InfectionsEscherichia coli O157FemaleHemolytic-Uremic SyndromeHumansInfantInfant, NewbornMaleMiddle AgedPhylogenyRetrospective StudiesEpidemiologyEscherichia coli (E. coli)phylogeneticsShiga toxin-producing E. coli

Identifiers

PMID29914582
PMCPMC6092231
OpenAlexW2809244473

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.