Evidence map›Paper›PMID 29914496›Full record

ArticleBMC medicine2018

Outcomes of neonates born following transfers of frozen-thawed cleavage-stage embryos with blastomere loss: a prospective, multicenter, cohort study.

Yan-Ting Wu, Cheng Li, Yi-Min Zhu, Shu-Hua Zou, Qiong-Fang Wu, Li-Ping Wang, Yan Wu, Rong Yin, Chao-Yi Shi, Jing Lin and 8 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
10.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Yan-Ting WuInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China.
Cheng LiInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China.
Yi-Min ZhuDepartment of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Shu-Hua ZouDepartment of Reproductive Medicine, Qingdao Women and Children's Hospital, Shandong, China.
Qiong-Fang WuDepartment of Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi, China.
Li-Ping WangDepartment of Reproductive Medicine, Jiaxing Maternity and Child Health Care Hospital, Zhejiang, China.
Yan WuDepartment of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Rong YinDepartment of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Chao-Yi ShiInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China.
Jing LinInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China.
Zi-Ru JiangInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China.
Yi-Jing XuInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China.
Yun-Fei SuInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China.
Jian ZhangInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China.
Jian-Zhong ShengDepartment of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Zhejiang, China.
William D FraserCentre de recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS) and Department of Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, QC, Canada.
Zhi-Wei LiuInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China. liuzhiwei@hotmail.com.
He-Feng HuangInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Rd, Shanghai, 200030, China. Huanghefg@sjtu.edu.cn.
Shanghai Jiao Tong University · CNWomen's Hospital, School of Medicine, Zhejiang University · CNJiangxi Maternal and Child Health Hospital · CNLishui Maternity and Child Health Care Hospital · CNMinistry of Education of the People's Republic of China · CNQingdao University · CNUniversité de Sherbrooke · CA

Funding

Medical Crossover Foundation of Shanghai Jiaotong University YG2015MS42National Key Research and Development Program of China 2016YFC1000203National Key Research and Development Program of China SQ2017YFSF080041National Natural Science Foundation of China 81490742National Natural Science Foundation of China 81661128010National Natural Science Foundation of China 81671412
6 · The paper itself

Abstract

backgroundDespite limited information on neonatal safety, the transfer of frozen-thawed cleavage-stage embryos with blastomere loss is common in women undergoing in vitro fertilization. We aimed to evaluate the pregnancy outcomes and safety of frozen-thawed cleavage-stage embryos with blastomere loss.

methodsThis prospective, multicenter, cohort study included all frozen-thawed cleavage-stage embryo transfer (FET) cycles between 2002 and 2012. Pregnancy outcomes and subsequent neonatal outcomes were compared between FET cycles with intact embryos and those with blastomere loss.

resultsA total of 12,105 FET cycles were included in the analysis (2259 cycles in the blastomere loss group and 9846 cycles in the intact embryo group). The blastomere loss group showed significantly poorer outcomes with respect to implantation, pregnancy, and live birth rates than the intact embryo group. However, following embryo implantation, the two groups were similar with respect to live birth rates per clinical pregnancy. Among multiple pregnancies (4229 neonates), neonates from the blastomere loss group were at an increased risk of being small for gestational age (aOR = 1.50, 95% CI 1.00-2.25) compared to those from the intact group. A similar trend was observed among singletons (aOR = 1.84, 95% CI 0.99-3.37). No associations were found between blastomere loss and the subsequent occurrence of congenital anomalies or neonatal mortality. However, neonates from the blastomere loss group were at an increased risk of transient tachypnea of the newborn (aOR = 5.21, 95% CI 2.42-11.22).

conclusionsThe transfer of embryos with blastomere loss is associated with reduced conception rates. Once the damaged embryos have implanted, pregnancies appear to have the same probability of progressing to live birth but with an increased risk of small for gestational age neonates and transient tachypnea of the newborn. STUDY REGISTRATION: This study was retrospectively registered at Chinese Clinical Trial Registry. Registration number: ChiCTR-OOC-16007753 . Registration date: 13 January 2016.

Indexed as

AdultBlastomeresCohort StudiesEmbryo ImplantationEmbryo TransferFemaleFertilization in VitroHumansInfant, NewbornPregnancyPregnancy OutcomeProspective StudiesBlastomere lossCohort studyFrozen embryo transferPregnancy outcomesSmall for gestational ageTransient tachypnea of the newborn

Identifiers

PMID29914496
PMCPMC6006714
OpenAlexW2809618862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.