Trial reportBMC health services research2018
Development of an exercise intervention for the prevention of musculoskeletal shoulder problems after breast cancer treatment: the prevention of shoulder problems trial (UK PROSPER).
Trial report in BMC health services research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06241404 (Efficacy of Therapeutic Exercise vs. Treatment of Myofascial Trigger Points in Shoulder Tendinopathies), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Therapeutic Exercise vs. Treatment of Myofascial Trigger Points in Shoulder Tendinopathies: Randomised Clinical Trial
Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Efficacy of a 4-Week Nurse-Led Exercise Rehabilitation Program in Improving the Quality of Life in Women Receiving a Post-Mastectomy Reconstruction Using the Motiva ErgonomixInternational journal of environmental research and public health · 2022Trial
- Exercise versus usual care after non-reconstructive breast cancer surgery (UK PROSPER): multicentre randomised controlled trial and economic evaluation.BMJ (Clinical research ed.) · 2021Trial
- Role of physiotherapy in supporting recovery from breast cancer treatment: a qualitative study embedded within the UK PROSPER trial.BMJ open · 2021Trial
- The feasibility of a complex intervention, a medical tattooing nurse-led clinic after breast cancer surgery: results from the ARCADE_M mixed-methods study.Scientific reports · 2025Article
- Telerehabilitation in Postoperative Breast Cancer Care: Systematic Review and Meta-Analysis.JMIR rehabilitation and assistive technologies · 2025Review
- Article
- Physical activity promotion in physical therapy, exercise therapy and other movement-based therapies: a scoping review and content analysis of intervention studies and theoretical works.The international journal of behavioral nutrition and physical activity · 2025Article
- Economic Evaluation in Physiotherapy or How to Get the Best Value for Money.Physiotherapy Canada. Physiotherapie Canada · 2025Article
- Intensity-modulated proton radiotherapy spares musculoskeletal structures in regional nodal irradiation for breast cancer: a dosimetric comparison.Acta oncologica (Stockholm, Sweden) · 2024Article
- Using Virtual Reality in a Rehabilitation Program for Patients With Breast Cancer: Phenomenological Study.JMIR serious games · 2024Article
- Effect of Integrated Survivorship Model on Physical Health for Breast Cancer Survivors in Rural Area.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Effects of Ultrasound-Guided Injection Combined with a Targeted Therapeutic Exercise in Breast Cancer Women with Subacromial Pain Syndrome: A Randomized Clinical Study.Journal of personalized medicine · 2022Article
- Article
- Quality Analysis of YouTube Videos Presenting Shoulder Exercises after Breast Cancer Surgery.Breast care (Basel, Switzerland) · 2022Article
- The Impact of Preoperative Distress: A Qualitative analysis of the Perioperative Pain Self-Management Intervention.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2022Article
- Association between Shoulder Range of Motion and Pain Catastrophizing Scale in Breast Cancer Patients after Surgery.Breast care (Basel, Switzerland) · 2021Article
- Article
- Current physical therapy care of patients undergoing breast reconstruction for breast cancer: a survey of practice in the United Kingdom and Brazil.Brazilian journal of physical therapyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMusculoskeletal shoulder problems are common after breast cancer treatment. There is some evidence to suggest that early postoperative exercise is safe and may improve shoulder function. We describe the development and delivery of a complex intervention for evaluation within a randomised controlled trial (RCT), designed to target prevention of musculoskeletal shoulder problems after breast cancer surgery (The Prevention of Shoulder Problems Trial; PROSPER).
methodsA pragmatic, multicentre RCT to compare the clinical and cost-effectiveness of best practice usual care versus a physiotherapy-led exercise and behavioural support intervention in women at high risk of shoulder problems after breast cancer treatment. PROSPER will recruit 350 women from approximately 15 UK centres, with follow-up at 6 and 12 months. The primary outcome is shoulder function at 12 months; secondary outcomes include postoperative pain, health related quality of life, adverse events and healthcare resource use. A multi-phased approach was used to develop the PROSPER intervention which was underpinned by existing evidence and modified for implementation after input from clinical experts and women with breast cancer. The intervention was tested and refined further after qualitative interviews with patients newly diagnosed with breast cancer; a pilot RCT was then conducted at three UK clinical centres. DISCUSSION: The PROSPER intervention incorporates three main components: shoulder-specific exercises targeting range of movement and strength; general physical activity; and behavioural strategies to encourage adherence and support exercise behaviour. The final PROSPER intervention is fully manualised with clear, documented pathways for clinical assessment, exercise prescription, use of behavioural strategies, and with guidance for treatment of postoperative complications. This paper adheres to TIDieR and CERT recommendations for the transparent, comprehensive and explicit reporting of complex interventions.
trial registrationInternational Standard Randomised Controlled Trial Number: ISRCTN 35358984 .
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.