ArticleBMC psychiatry2018
Olfactory impairment in first-episode schizophrenia: a case-control study, and sex dimorphism in the relationship between olfactory impairment and psychotic symptoms.
Article in BMC psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Sex and gender differences in symptoms of early psychosis: a systematic review and meta-analysis.Archives of women's mental health · 2022Pooled it
- Elucidating the Complex Etiology of Schizophrenia: Comprehensive Insights into the Therapeutic Roles of Natural Compounds and Pharmacological Interventions.Current pharmaceutical design · 2026Review
- Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders.Molecular psychiatry · 2024Article
- Cognitive behavioral therapy for a Japanese woman with olfactory reference disorder (ORD) comorbid with schizophrenia: A case study.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Text-based predictions of COVID-19 diagnosis from self-reported chemosensory descriptions.Communications medicine · 2023Article
- Olfactory Dysfunction in Mental Illness.Current allergy and asthma reports · 2023Review
- Brain regions associated with olfactory dysfunction in first episode psychosis patients.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2023Article
- Olfactory Dysfunction in Schizophrenia: Evaluating Olfactory Abilities Across Species.Current topics in behavioral neurosciences · 2023Review
- Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?Translational psychiatry · 2022Review
- Odor Identification Ability as a Mediator of Schizotypal Traits and Odor Hedonic Capacity in Non-Clinical Children and Adolescents.Brain sciences · 2022Article
- Olfactory interference on the emotional processing speed of visual stimuli: The influence of facial expressions intensities.PloS one · 2022Article
- Sex Differences in Odor Hedonic Perception: An Overview.Frontiers in neuroscience · 2021Review
- Association Between Anxious Symptom Severity and Olfactory Impairment in Young Adults with Generalized Anxiety Disorder: A Case-Control Study.Neuropsychiatric disease and treatment · 2021Article
- Blunt olfaction in sexually sluggish male rats.Experimental animals · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA body of studies has focused on the olfactory impairment among people with schizophrenia. The effect of sex on this relationship has attracted the attention of researchers. These issues have not been studied much in Chinese schizophrenia patients.
methodsWe conducted a case-control study of 110 first-episode antipsychotic medicine naïve schizophrenia patients aged 18-35 years and 110 controls, matched by age and sex. Odour threshold, discrimination and identification were assessed by the "Sniffin' Sticks" test. Psychotic symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS).
resultsThe odour threshold, discrimination and identification scores of patients with schizophrenia were significantly lower than those of the healthy control group. The difference in identification score had statistical significance between male and female patients with schizophrenia (t = - 2.45, P < 0.05). Controlling for confounding factor, in male schizophrenia participants, the negative subscale score was significantly and inversely correlated with the discrimination (γ = - 0.37, p < 0.008), identification (γ = - 0.45, p < 0.008) and TDI (γ = - 0.50, p < 0.008) scores; the general psychopathology subscale score was inversely and significantly correlated with the identification (γ = - 0.47, p < 0.008) and TDI (γ = - 0.41, p < 0.008) scores. For female schizophrenia patients, positive and general psychopathology subscale scores had a significant inverse correlation with the identification score (positive: γ = - 0.47, p < 0.008; general psychopathology: γ = - 0.42, p < 0.008).
conclusionsControlling for confounder, negative symptoms were related to impaired odour discrimination and identification in male schizophrenia patients, while positive symptoms were correlated with impaired odour identification in female schizophrenia patients. This sex dimorphism could provide useful information for future studies aiming to finding biomarkers of schizophrenia.
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