ReviewInternational journal of molecular sciences2018
Bioengineering Approaches for Bladder Regeneration.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Current evidence regarding alternative techniques for enterocystoplasty using regenerative medicine methods: a systematic review.European journal of medical research · 2024Pooled it
- Review of clinical experience on biomaterials and tissue engineering of urinary bladder.World journal of urology · 2020Pooled it
- Multifunctional VEGF/CeOPharmaceutics · 2026Article
- The engineered bladder patch with a three-layer structure promotes the regeneration and functional recovery of the bladder in a rabbit model.Bioengineering & translational medicine · 2026Article
- Development of anMatrix biology plus · 2025Article
- Recent advances and future directions in urinary system tissue engineering.Materials today. Bio · 2025Review
- Stem cell therapy for bladder regeneration: A comprehensive systematic review.Regenerative therapy · 2025Review
- Cell-free biodegradable electroactive scaffold for urinary bladder tissue regeneration.Nature communications · 2025Article
- Engineering the Future of Bladder Repair: Can Biocompatible 3D-Printed Scaffolds Serve as a Novel Alternative to Intestinal Segments for the Treatment of Bladder Exstrophy?Advances in urology · 2025Article
- Emergent biotechnology applications in urology: a mini review.Frontiers in bioengineering and biotechnology · 2025Review
- [Application and progress of bio-derived materials in bladder regeneration and repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Review
- Efficient decellularization of human fetal kidneys through optimized SDS exposure.Scientific reports · 2024Article
- Bladder Reconstruction in Cats Using In-Body Tissue Architecture (iBTA)-Induced Biosheet.Bioengineering (Basel, Switzerland) · 2024Article
- The Effect of Multilayered Electrospun PLLA Nanofibers Coated with Human Amnion or Bladder ECM Proteins on Epithelialization and Smooth Muscle Regeneration in the Rabbit Bladder.Macromolecular bioscience · 2024Article
- Engineering pedicled vascularized bladder tissue for functional bladder defect repair.Bioengineering & translational medicine · 2023Article
- Tissue Engineering and Stem Cell Therapy in Neurogenic Bladder Dysfunction: Current and Future Perspectives.Medicina (Kaunas, Lithuania) · 2023Review
- Current Viewpoint on Female Urogenital Microbiome-The Cause or the Consequence?Microorganisms · 2023Review
- Preliminary In Vitro Assessment of Decellularized Porcine Descending Aorta for Clinical Purposes.Journal of functional biomaterials · 2023Article
- Partial cystectomy for bladder squamous cell carcinoma with a 10-year follow-up: a case report.Frontiers in oncology · 2023Article
- From waste to wealth: Repurposing slaughterhouse waste for xenotransplantation.Frontiers in bioengineering and biotechnology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current clinical strategies for bladder reconstruction or substitution are associated to serious problems. Therefore, new alternative approaches are becoming more and more necessary. The purpose of this work is to review the state of the art of the current bioengineering advances and obstacles reported in bladder regeneration. Tissue bladder engineering requires an ideal engineered bladder scaffold composed of a biocompatible material suitable to sustain the mechanical forces necessary for bladder filling and emptying. In addition, an engineered bladder needs to reconstruct a compliant muscular wall and a highly specialized urothelium, well-orchestrated under control of autonomic and sensory innervations. Bioreactors play a very important role allowing cell growth and specialization into a tissue-engineered vascular construct within a physiological environment. Bioprinting technology is rapidly progressing, achieving the generation of custom-made structural supports using an increasing number of different polymers as ink with a high capacity of reproducibility. Although many promising results have been achieved, few of them have been tested with clinical success. This lack of satisfactory applications is a good reason to discourage researchers in this field and explains, somehow, the limited high-impact scientific production in this area during the last decade, emphasizing that still much more progress is required before bioengineered bladders become a commonplace in the clinical setting.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.