Evidence map›Paper›PMID 29914211›Full record

ArticleMolecules (Basel, Switzerland)2018

Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo.

Sang-Bum Kim, Kyu-Sang Kim, Heon-Min Ryu, Seong-Ho Hong, Bo-Kyoung Kim, Dae-Duk Kim, Jin Woo Park, In-Soo Yoon

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Inhibition of Rat CYP1A2 and CYP2C11 by Honokiol, a Component of Traditional Chinese Medicine.European journal of drug metabolism and pharmacokinetics · 2019
    Article
  5. Article
  6. Insights on the Multifunctional Activities of Magnolol.BioMed research international · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sang-Bum KimNew Drug Development Center, Daegu‒Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea. ksb2014@dgmif.re.kr.
Kyu-Sang KimCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea. kyuritas00@naver.com.
Heon-Min RyuCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea. newrhm@snu.ac.kr.
Seong-Ho HongBiomedicine Lab, CKD Research Institute, Gyeonggi 16995, Korea. duck1240@naver.com.
Bo-Kyoung KimNew Drug Development Center, Daegu‒Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea. kbky9872@gmail.com.
Dae-Duk KimCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea. ddkim@snu.ac.kr.
Jin Woo ParkDepartment of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Korea. jwpark@mokpo.ac.kr.
In-Soo YoonDepartment of Manufacturing Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea. insoo.yoon@pusan.ac.kr.ORCID 0000-0002-0997-5723
Seoul National University · KRDaegu-Gyeongbuk Medical Innovation Foundation · KRMokpo National University · KRPusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Honokiol (2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol) and magnolol (4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol) are the major active polyphenol constituents of

Indexed as

Administration, IntravenousAllyl CompoundsAnimalsBiphenyl CompoundsChromatography, High Pressure LiquidCytochrome P-450 CYP1A1Cytochrome P-450 Enzyme SystemDiclofenacDrug InteractionsGene Expression RegulationLignansLiverMicrosomes, LiverMolecular StructurePhenacetinPhenolsAllyl CompoundsBiphenyl CompoundsCytochrome P-450 CYP1A1cytochrome P-450 CYP2C subfamilyCytochrome P-450 Enzyme SystemDiclofenachonokiolLignansmagnololPhenacetinPhenolsCYP1ACYP2ChonokiolMagnolia officinalismagnololpharmacokineticsrat

Identifiers

PMID29914211
PMCPMC6100004
OpenAlexW2808198586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.