Evidence map›Paper›PMID 29914196›Full record

ArticleMolecules (Basel, Switzerland)2018

Anti-Proliferation Effect of Theasaponin E₁ on the ALDH-Positive Ovarian Cancer Stem-Like Cells.

Ling-Yan Jia, Hui-Long Xia, Zhi-Da Chen, Casey Compton, Heather Bucur, Devendra A Sawant, Gary O Rankin, Bo Li, You-Ying Tu, Yi Charlie Chen

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Theasaponin EMolecules (Basel, Switzerland) · 2021
    Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ling-Yan JiaDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China. 11416013@zju.edu.cn.
Hui-Long XiaSchool of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou 310018, China. hlxia@zjgsu.edu.cn.
Zhi-Da ChenDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China. 21616101@zju.edu.cn.
Casey ComptonCollege of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA. ccompton@k12.wv.us.
Heather BucurCollege of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA. bucurhm@battlers.ab.edu.
Devendra A SawantSchool of Anatomical Science, Alderson Broaddus University, College of Medical Science, Philippi, WV 26416, USA. drdsawant@gmail.com.
Gary O RankinDepartment of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. rankin@marshall.edu.
Bo LiDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China. drlib@zju.edu.cn.
You-Ying TuDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China. youytu@zju.edu.cn.
Yi Charlie ChenCollege of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA. chenyc@ab.edu.ORCID 0000-0001-6865-9512

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Ovarian cancer has the highest mortality rate of all gynecological malignancies and the five-year death rate of patients has remained high in the past five decades. Recently, with the rise of cancer stem cells (CSCs) theory, an increasing amount of research has suggested that CSCs give rise to tumor recurrence and metastasis. Theasaponin E₁ (TSE₁), which was isolated from green tea (

Indexed as

Aldehyde DehydrogenaseBiomarkersCell ProliferationDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansMolecular StructureNeoplastic Stem CellsOleanolic AcidOvarian NeoplasmsSaponinsTeaAldehyde DehydrogenaseBiomarkersOleanolic AcidSaponinsTeatheasaponin E1ALDHCamellia sinensiscancer stem cellsovarian cancertheasaponin E1

Identifiers

PMID29914196
PMCPMC6057729

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.