Evidence map›Paper›PMID 29914095›Full record

Trial reportNutrients2018

Dose-Dependent Effects of Multispecies Probiotic Supplementation on the Lipopolysaccharide (LPS) Level and Cardiometabolic Profile in Obese Postmenopausal Women: A 12-Week Randomized Clinical Trial.

Monika Szulińska, Igor Łoniewski, Saskia van Hemert, Magdalena Sobieska, Paweł Bogdański

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04089280 (The Effect of Multi-strain Probiotics on Gastrointestinal Symptoms in Patients With Type 2 Diabetes and Metformin Intolerance. A 32-week Prospective, Single Center, Randomized, Placebo Controlled, Cross-over Clinical Trial.), which is not on this map. Cited by 87 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 8 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04089280 nacompletednot on this map

The Effect of Multi-strain Probiotics on Gastrointestinal Symptoms in Patients With Type 2 Diabetes and Metformin Intolerance. A 32-week Prospective, Single Center, Randomized, Placebo Controlled, Cross-over Clinical Trial.

TypeinterventionalSponsorMedical University of SilesiaRan2018 to 2021Enrolled37ConditionsDiabetes Mellitus, Type 2, Metformin Adverse ReactionArmsSanprobi Barrier-multispecies probiotic, Placebo Comparator
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 8 syntheses or guidelines pooled it, 184 citations in OpenAlex.

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  17. Effect of probioticWorld journal of gastroenterology · 2021
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  19. Effect ofNutrients · 2019
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Monika SzulińskaDepartment of Education and Treatment of Obesity and Metabolic Disorders, University of Medical Sciences in Poznań, Szamarzewskiego Str. 84, 60-569 Poznań, Poland. mszulinska1@wp.pl.
Igor ŁoniewskiDepartment of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Broniewskiego Str. 24, 71-460 Szczecin, Poland. sanprobi@sanprobi.pl.
Saskia van HemertWinclove Probiotics, Hulstweg 11, 1032 LB Amsterdam, The Netherlands. s.vanhemert@winclove.nl.
Magdalena SobieskaDepartment of Rheumatology and Rehabilitation, University of Medical Sciences in Poznań, 28 Czerwca 1956r Str. 135/147, 61-55 Poznań, Poland. msobieska@ump.edu.pl.ORCID 0000-0001-5341-8708
Paweł BogdańskiDepartment of Education and Treatment of Obesity and Metabolic Disorders, University of Medical Sciences in Poznań, Szamarzewskiego Str. 84, 60-569 Poznań, Poland. pawelbogdanski73@gmail.com.
Poznan University of Medical Sciences · PLPomeranian Medical University · PLWinclove Probiotics (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the postmenopausal period, the risk of cardiovascular diseases is increased in many obese women and is associated with a worse cardiometabolic profile and a sub-chronic low-grade systemic inflammation caused by a gut barrier permeability dysfunction. Here, we tested whether administration of two different dosages of the multispecies probiotic Ecologic

Indexed as

AdultAgedCardiovascular DiseasesDose-Response Relationship, DrugFemaleHumansLipopolysaccharidesMiddle AgedObesityPostmenopauseProbioticsLipopolysaccharidesmetabolic profileobesitypostmenopausal womenprobiotics

Identifiers

PMID29914095
PMCPMC6024794
OpenAlexW2808223642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.