Evidence map›Paper›PMID 29914081›Full record

ArticleCancers2018

Loss of Cyclin-Dependent Kinase Inhibitor Alters Oncolytic Adenovirus Replication and Promotes More Efficient Virus Production.

Naseruddin Höti, Tamara Jane Johnson, Wasim H Chowdhury, Ronald Rodriguez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Naseruddin HötiDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. nhoti1@jhmi.edu.
Tamara Jane JohnsonJames Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. tamarajane.johnson@gmail.com.
Wasim H ChowdhuryDepartment of Urology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA. ChowdhuryW@uthscsa.edu.ORCID 0000-0002-6731-646X
Ronald RodriguezDepartment of Urology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA. rodriguezR32@uthscsa.edu.
Johns Hopkins University · USThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We elucidate the role of p21/Waf-1, a cyclin-dependent kinase inhibitor, on the oncolytic infection and replication cycle of adenovirus by studying both mRNA and adenoviral proteins expression. We found that infection in the absence of p21 causes a significant increase in adenoviral genomes and late gene expression. Similarly, the oncolytic adenoviral infected p21

Indexed as

adenovirus replicationoncolytic adenovirusp21

Identifiers

PMID29914081
PMCPMC6025342
OpenAlexW2808207717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.