ReviewViruses2018
The Diversity of Bacterial Lifestyles Hampers Bacteriophage Tenacity.
Review in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Harnessing phages to tackle antimicrobial resistance: a Saudi Arabian perspective.Frontiers in cellular and infection microbiology · 2025Review
- A diverse set of Enterococcus-infecting phage provides insight into phage host-range determinants.Virus research · 2024Article
- Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo.Nature communications · 2024Article
- High-Throughput Bacteriophage Testing with Potency Determination: Validation of an Automated Pipetting and Phage Drop-Off Method.Biomedicines · 2024Article
- Phage Paride can kill dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa by direct lytic replication.Nature communications · 2024Article
- Adaptive lifestyle of bacteria determines phage-bacteria interaction.Frontiers in microbiology · 2022Article
- Community context matters for bacteria-phage ecology and evolution.The ISME journal · 2021Review
- Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis.BMC biology · 2021Article
- Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles.Polymers · 2021Article
- Article
- New insights into intestinal phages.Mucosal immunology · 2020Review
- Shining Light on Human Gut Bacteriophages.Frontiers in cellular and infection microbiology · 2020Review
- Resistance Evolution against Phage Combinations Depends on the Timing and Order of Exposure.mBio · 2019Article
- Development of a Biocontrol Method Applying Bacteriophage-Containing Aerosol againstMicroorganisms · 2019Article
- Article
- Spatial structure affects phage efficacy in infecting dual-strain biofilms ofCommunications biology · 2019Article
- Antibiotic Therapy Using Phage Depolymerases: Robustness Across a Range of Conditions.Viruses · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phage therapy is based on a simple concept: the use of a virus (bacteriophage) that is capable of killing specific pathogenic bacteria to treat bacterial infections. Since the pioneering work of Félix d’Herelle, bacteriophages (phages) isolated in vitro have been shown to be of therapeutic value. Over decades of study, a large number of rather complex mechanisms that are used by phages to hijack bacterial resources and to produce their progeny have been deciphered. While these mechanisms have been identified and have been studied under optimal conditions in vitro, much less is known about the requirements for successful viral infections in relevant natural conditions. This is particularly true in the context of phage therapy. Here, we highlight the parameters affecting phage replication in both in vitro and in vivo environments, focusing, in particular, on the mammalian digestive tract. We propose avenues for increasing the knowledge-guided implementation of phages as therapeutic tools.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.