ArticleJournal of the American Academy of Dermatology2018
Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia.
Article in Journal of the American Academy of Dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
1470 nm Non-Ablative Laser for the Treatment of Scarring Alopecia: A Clinical and Mechanistic Study
Tirzepatide for Treatment of CCCA
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis.Acta dermato-venereologica · 2026Pooled it
- Unravelling the transcriptomic landscape of primary lymphocytic scarring alopecias: systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Trichotillomania preceding central centrifugal cicatricial alopecia in a pediatric patient.JAAD case reports · 2026Article
- Cross-species comparative spatial transcriptomics of hair follicle-T cell interactions identifies conserved drivers of cutaneous lupus erythematosus skin disease and associated hair loss.Nature communications · 2026Article
- Afro-textured hair care: a narrative review and recommendations for dermatologists.International journal of women's dermatology · 2026Review
- Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance.Frontiers in medicine · 2026Review
- Atgl-Dependent Adipocyte Lipolysis Promotes Lipodystrophy and Restrains Fibrogenic Responses during Skin Fibrosis.The Journal of investigative dermatology · 2025Article
- Using Disease Symptomatology to Guide Treatment in Patients with Central Centrifugal Cicatricial Alopecia: Introduction of C-CAT Scoring Tool.Skin appendage disorders · 2025Article
- Adjuvant use of topical metformin with standard therapies in recalcitrant central centrifugal cicatricial alopecia: A case series.JAAD case reports · 2025Article
- A Pilot Study Characterization of the Scalp Microbiome in Central Centrifugal Cicatricial Alopecia Shows Shift inSkin appendage disorders · 2025Article
- M2 Macrophage and Extracellular Matrix Genes Are Enriched in High-Activity Lichen Planopilaris.Dermatology research and practice · 2025Article
- Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation.JID innovations : skin science from molecules to population health · 2024Article
- Risk factors and comorbidities associated with central centrifugal cicatricial alopecia.International journal of women's dermatology · 2023Review
- Clinical factors and hair care practices influencing outcomes in central centrifugal cicatricial alopecia.Archives of dermatological research · 2023Article
- Central centrifugal cicatricial alopecia in Black men: A case series highlighting key clinical features in this cohort.JAAD case reports · 2023Article
- Dermatological Conditions in SKIN OF COLOR- A Practical Approach to Centrifugal Cicatricial Alopecia.The Journal of clinical and aesthetic dermatology · 2023Article
- Granzyme B in Autoimmune Skin Disease.Biomolecules · 2023Review
- Primary cicatricial alopecias are characterized by dysregulation of shared gene expression pathways.PNAS nexus · 2022Article
- Immune-mediated alopecias and their mechanobiological aspects.Cells & development · 2022Review
- Gene expression profiling suggests severe, extensive central centrifugal cicatricial alopecia may be both clinically and biologically distinct from limited disease subtypes.Experimental dermatology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCentral centrifugal cicatricial alopecia (CCCA) is a primary cicatricial alopecia that most commonly affects women of African descent. Like CCCA, fibroproliferative disorders (FPDs) such as keloids, atherosclerosis, and fibroids are characterized by low-grade inflammation and irritation, resulting in end-stage fibrosis.
objectiveWe sought to determine whether fibroproliferative genes were up-regulated in patients with CCCA.
methodsA total of 5 patients with biopsy-proven CCCA were recruited for this study. Two scalp biopsy specimens were obtained from each patient; 1 from CCCA-affected vertex scalp and 1 from the unaffected occipital scalp. Microarray analysis was performed to determine the differential gene expression patterns.
resultsThere was an upregulation of genes implicated in FPDs in patients with CCCA. Specifically, we noted increased expression of platelet derived growth factor gene (PDGF), collagen I gene (COL I), collagen III gene (COL III), matrix metallopeptidase 1 gene (MMP1), matrix metallopeptidase 2 gene (MMP2), matrix metallopeptidase 7 gene (MMP7), and matrix metallopeptidase 9 gene (MMP9) in affected scalp compared with in unaffected scalp. Significant overlap in the canonic pathways was noted between patients with CCCA and patients with both atherosclerosis and hepatic fibrosis (P < .001). LIMITATIONS: Small sample size and the use of whole skin tissue for analysis.
conclusionWe have identified the upregulation of critical genes implicated in FPDs in the gene expression profile of patients with CCCA. These findings may help identify future therapeutic targets for this otherwise difficult-to-treat condition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.