Evidence map›Paper›PMID 29913094›Full record

ArticleJournal of dental research2018

Defective NaCl Reabsorption in Salivary Glands of Eda-Null X-LHED Mice.

T Mukaibo, T Munemasa, C Masaki, C Y Cui, J E Melvin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Cell signaling regulation in salivary gland development.Cellular and molecular life sciences : CMLS · 2021
    Review
  2. Slc26a6 is an apical membrane anion exchanger that drives HCOAmerican journal of physiology. Cell physiology · 2019
    Article
  3. Article
  4. The apical NaJournal of cellular physiology · 2019
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

T Mukaibo1 Secretory Mechanisms and Dysfunctions Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
T Munemasa1 Secretory Mechanisms and Dysfunctions Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
C Masaki2 Department of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan.
C Y Cui3 Laboratory of Genetics and Genomics, National Institute of Aging, National Institutes of Health, Baltimore, MD, USA.
J E Melvin1 Secretory Mechanisms and Dysfunctions Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
National Institute of Dental and Craniofacial Research · USNational Institutes of Health · USKyushu Dental University · JP

Funding

NIDCR DIR Secretory Mechanisms and Dysfunctions SectionZIADE000738 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MELVIN, JAMES · 2011 to 2019
$14.4M
NIDCR Annual Reports - Veterinary Resources CoreZIGDE000740 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DAVIDSON, LAUREN · 2012 to 2025
$11.7M
Intramural NIH HHS ZIA DE000738Intramural NIH HHS ZIG DE000740NIDCR NIH HHS ZIG DE000740
6 · The paper itself

Abstract

Mutations in the ectodysplasin A gene ( EDA) cause X-LHED (X-linked hypohidrotic ectodermal dysplasia), the most common human form of ectodermal dysplasia. Defective EDA signaling is linked to hypoplastic development of epithelial tissues, resulting in hypotrichosis, hypodontia, hypohidrosis, and xerostomia. The primary objective of the present study was to better understand the salivary gland dysfunction associated with ectodermal dysplasia using the analogous murine disorder. The salivary flow rate and ion composition of the 3 major salivary glands were determined in adult Eda-deficient Tabby hemizygous male (Ta/Y) and heterozygous female (Ta/X) mice. Submandibular and sublingual glands of Eda-mutant mice were smaller than wild-type littermates, while parotid gland weight was not significantly altered. Fluid secretion by the 3 major salivary glands was essentially unchanged, but the decrease in submandibular gland size was associated with a dramatic loss of ducts in Ta/Y and Ta/X mice. Reabsorption of Na

Indexed as

AnimalsEctodermal Dysplasia 1, AnhidroticEctodysplasinsFemaleMaleMiceMice, Inbred C57BLMutationOrgan SizePolymerase Chain ReactionSalivary GlandsSalivationSodium ChannelsSodium ChlorideSubmandibular GlandEctodysplasinsEda protein, mouseSodium ChannelsSodium Chloridecystic fibrosis transmembrane conductance regulatorepithelial sodium channelsfluids and secretionshidrotic ectodermal dysplasiasalivary glandsScnn1

Identifiers

PMID29913094
PMCPMC6151911
OpenAlexW2809173956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.