SynthesisPloS one2018
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 8 pooled it
200.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,169 citations in OpenAlex.
- Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Translational psychiatry · 2025Pooled it
- Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study.Nature communications · 2023Pooled it
- Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.BMC genomics · 2023Pooled it
- Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review.Frontiers in nutrition · 2023Pooled it
- Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.Molecular psychiatry · 2021Pooled it
- Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions.European journal of human genetics : EJHG · 2021Pooled it
- Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.Nature communications · 2020Pooled it
- Genome-wide study of immune biomarkers in cerebrospinal fluid and serum from patients with bipolar disorder and controls.Translational psychiatry · 2020Pooled it
- BMI-Dependent Associations of the Estradiol-Linked Polymorphism rs117585797 of theLife (Basel, Switzerland) · 2026Article
- Multi-trait GWAS reveals divergent local and polygenic architecture of cardiovascular traits across African and European ancestries in the UK Biobank.Communications biology · 2026Article
- Discovery of gene-alcohol interaction loci influencing blood pressure in 1.1 million individuals from multiple populations.Research square · 2026Article
- An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank.PLoS genetics · 2026Article
- Both Fetal and Maternal Genotypes Affect Preeclampsia Pathogenesis in Iranian Patients.Biochemical genetics · 2026Article
- SNP-based prediction of schizophrenia using machine learning.Bioinformatics advances · 2026Article
- Exploring the genetic basis of essential hypertension: association with AGT gene variants in an Iranian population.BMC genomics · 2025Article
- Genetic factors in the risk assessment of preeclampsia: a review of recent findings.Molecular biology reports · 2025Review
- Sex Difference of Alcoholic Hypertension: Mechanism and Targeted Therapy.Current hypertension reports · 2025Review
- Comprehensive genome-wide analysis of retinal vessel caliber reveals microvascular-blood pressure pathways: advancing predictive, preventive, and personalized medicine.The EPMA journal · 2025Article
- Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Harnessing the power of genomics in hypertension: tip of the iceberg?Cambridge prisms. Precision medicine · 2025Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
274 authors at 20 institutions in 23 countries.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0002-0933-2410
Aldi T KrajaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Daniel I ChasmanPreventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Yun J SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.ORCID 0000-0003-0292-5421
Ioanna NtallaClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Xiuqing GuoGenomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Nora FranceschiniEpidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, North Carolina, United States of America.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Xueling SimSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Dina VojinovicDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jonathan MartenMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Solomon K MusaniJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Changwei LiEpidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, Georgia, United States of America.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.ORCID 0000-0002-0827-9101
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.ORCID 0000-0002-5235-9037
Karen SchwanderDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Melissa A RichardBrown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Raymond NoordamInternal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Hugues AschardDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
Traci M BartzCardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, Washington, United States of America.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Virginia FisherBiostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Fernando P HartwigPostgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.
Andrea R V R HorimotoLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.
Kurt K LohmanBiostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Alisa K ManningClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Salman M TajuddinHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.ORCID 0000-0002-7919-8528
Mary K WojczynskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Maris AlverEstonian Genome Center, University of Tartu, Tartu, Estonia.
Mathilde BoisselCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Archie CampbellCentre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0003-0198-5078
Jin Fang ChaiSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.ORCID 0000-0003-3770-1137
Xu ChenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden.ORCID 0000-0002-7299-3238
Jasmin DiversBiostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Chuan GaoMolecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Anuj GoelDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.
Yanick HagemeijerDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-6036-3741
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
Meian HeDepartment of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fang-Chi HsuBiostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Anuradhani KasturiratneDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Pirjo KomulainenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Brigitte KühnelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Federica LaguzziUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Nana MatobaLaboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.ORCID 0000-0001-5329-0134
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
Muhammad RiazDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.ORCID 0000-0002-5512-1745
Rico RueediDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6713-2214
Antonietta RobinoInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.
M Abdullah SaidDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-2920-7745
Robert A ScottMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Tamar SoferDepartment of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Alena StančákováInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Bamidele O TayoDepartment of Public Health Sciences, Loyola University Chicago, Maywood, Illinois, United States of America.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-8450-3518
Tibor V VargaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
Veronique VitartMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Yajuan WangDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America.
Erin B WareSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.ORCID 0000-0003-4731-8158
Helen R WarrenClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Stefan WeissInterfaculty Institute for Genetics and Functional genomics, University Medicine Ernst Moritz Arndt University Greifsald, Greifswald, Germany.ORCID 0000-0002-3553-4315
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Lisa R YanekDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Saima AfaqDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Marzyeh AminiDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-0123-9510
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Eric BoerwinkleDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, United States of America.
Ingrid BoreckiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Ulrich BroeckelSection of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Morris BrownClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Marco BrumatDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Gregory L BurkePublic Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Mickaël CanouilCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.ORCID 0000-0002-3396-4549
Aravinda ChakravartiMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Sabanayagam CharumathiSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Yii-Der Ida ChenGenomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America.
John M ConnellNinewells Hospital & Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
Adolfo CorreaJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Lisa de las FuentesDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Renée de MutsertClinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
H Janaka de SilvaDepartment of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Xuan DengBiostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Jingzhong DingCenter on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America.
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Charles B EatonDepartment of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.
Georg EhretCardiology, Geneva University Hospital, Geneva, Switzerland.
Ruben N EppingaDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.ORCID 0000-0002-5488-2999
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.
Stephan B FelixDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Terrence ForresterThe Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Yechiel FriedlanderBraun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Ilaria GandinDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
He GaoDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Bruna GiganteUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
C Charles GuDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Dongfeng GuDepartment of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Saskia P HagenaarsCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
Göran HallmansDepartment of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Västerbotten, Sweden.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Jiang HeEpidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
Sami HeikkinenInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-6083-2402
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Makoto HirataLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.
Barbara V HowardMedStar Health Research Institute, Hyattsville, Maryland, United States of America.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
InterAct Consortium
Ulrich JohnDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Tomohiro KatsuyaDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.
Chiea Chuen KhorGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Woon-Puay KohSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
José E KriegerLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.
Stephen B KritchevskySticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Michiaki KuboCenter for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Timo A LakkaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Carl D LangefeldBiostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Benjamin LehneDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Cora E LewisDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Yize LiDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Shiow LinDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Jianjun LiuSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Jingmin LiuWHI CCC, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Marie LohDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Tin LouieDepartment of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Colin A McKenzieThe Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.ORCID 0000-0002-3718-796X
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu, Estonia.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Yukihide MomozawaLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Mike A NallsData Tecnica International, Glen Echo, Maryland, United States of America.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington, United States of America.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, Aurora, Colorado, United States of America.
Jeff R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Nicholette D PalmerBiochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Thomas PerlsGeriatrics Section, Boston University Medical Center, Boston, Massachusetts, United States of America.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Neil PoulterSchool of Public Health, Imperial College London, London, London, United Kingdom.
Leslie J RaffelDivision of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, California, United States of America.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Kathryn RollGenomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Lynda M RosePreventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Frits R RosendaalClinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Jerome I RotterGenomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Carsten O SchmidtInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Pamela J SchreinerEpidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
Nicole SchupfTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.
William R ScottDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Peter S SeverNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0003-0421-2409
Yuan ShiSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Stephen SidneyDivision of Research, Kaiser Permanente of Northern California, Oakland, California, United States of America.
Mario SimsJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Colleen M SitlaniCardiovascular Health Research Unit, Medicine, University of Washington, Seattle, Washington, United States of America.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Nicholas Y Q TanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Hua TangDepartment of Genetics, Stanford University, Stanford, California, United States of America.
Kent D TaylorGenomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Yik Ying TeoSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Yih Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Peter VollenweiderService of Internal Medicine, Department of Internal Medicine, University Hospital, Lausanne, Switzerland.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Lihua WangDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Ya Xing WangBeijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.
Wen Bin WeiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Christine WilliamsDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Jie YaoGenomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Caizheng YuDepartment of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jian-Min YuanDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Alan B ZondermanBehavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.
Diane M BeckerDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Donald W BowdenBiochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.
Martin FarrallDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
Barry I FreedmanNephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Philippe FroguelCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Paolo GaspariniInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Jost Bruno JonasBeijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.ORCID 0000-0003-2972-5227
Yoichiro KamataniLaboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, Middlesex, United Kingdom.
Zoltán KutalikSwiss Instititute of Bioinformatics, Lausanne, Switzerland.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Karin LeanderUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Lifelines Cohort StudyLifelines Cohort, Groningen, The Netherlands.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden.
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Ozren PolasekDepartment of Public Health, Department of Medicine, University of Split, Split, Croatia.
David J PorteousCentre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
James ScottNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lynne E WagenknechtPublic Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-1422-2993
Hugh WatkinsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.
Ananda R WickremasingheDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Tangchun WuDepartment of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Kaare ChristensenThe Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Michele K EvansHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Bernardo L HortaPostgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Yongmei LiuPublic Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America.
Alexandre C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.
Bruce M PsatyCardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington, United States of America.
Paul M RidkerPreventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Rob M van DamSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
W James GaudermanBiostatistics, Preventive Medicine, University of Southern California, Los Angeles, California, United States of America.
Xiaofeng ZhuDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America.
Dennis O Mook-KanamoriClinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Myriam FornageHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
L Adrienne CupplesBiostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Tanika N KellyEpidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
Ervin R FoxCardiology, Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
E Shyong TaiSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Charles KooperbergFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, Washington, United States of America.
Walter PalmasMedicine, Columbia University Medical Center, New York, New York, United States of America.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, Washington, United States of America.ORCID 0000-0002-3071-7278
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Paul ElliottMRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.ORCID 0000-0002-7511-5684
Mark J CaulfieldClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Patricia B MunroeClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Daniel LevyThe Framingham Heart Study, Framingham, Massachusetts, United States of America.
Washington University in St. Louis · USWake Forest University · USUniversity of Michigan · USNational University of Singapore · SGUniversity Medical Center Groningen · NLImperial College London · GBNational Institutes of Health · USUniversity of Washington · USAgency for Science, Technology and Research · SGErasmus MC · NLHelmholtz Zentrum München · DEKarolinska Institutet · SEQueen Mary University of London · GBThe Lundquist Institute · USUniversity of Cambridge · GBUniversity of Eastern Finland · FIBeijing Tongren Hospital · CNBoston University · USBrigham and Women's Hospital · USInstitute of Genetics and Cancer · GB
Funding
HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8MHealthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS)ZIAAG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$70.9MGenetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MLong Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2MRole of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MThe Underlying Biology of Health DisparitiesZIAAG000519 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$15.7MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MBiotechnology and Biological Sciences Research Council BB/F019394/1British Heart Foundation SP/13/2/30111Medical Research Council G0601966Medical Research Council G0700931Medical Research Council MC_PC_U127561128Medical Research Council MC_UP_1605/7Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/5Medical Research Council MC_UU_12015/7Medical Research Council MR/K002414/1Medical Research Council MR/L01341X/1Medical Research Council MR/M013111/1NCI NIH HHS P01 CA196569NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R21 HL123677NIA NIH HHS R01 AG055406NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG023746NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01 DK117445NIDDK NIH HHS U01 DK062370NIEHS NIH HHS P30 ES010126NIGMS NIH HHS P20 GM121334NIMHD NIH HHS R01 MD012765Wellcome Trust
Abstract
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in ≈131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P < 1.0 x 10-5). In Stage 2, these SNVs were tested for independent external replication in ≈440K individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10-8). For African ancestry samples, we detected 18 potentially novel BP loci (P < 5.0 x 10-8) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2) have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.
Indexed as
Polymorphism, Single NucleotideRacial GroupsAdolescentAdultAgedAged, 80 and overAlcohol DrinkingBlood PressureCohort StudiesFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHypertensionMale
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.