ArticlePloS one2018
Associations between waist circumference, metabolic risk and executive function in adolescents: A cross-sectional mediation analysis.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Diet, lifestyle, metabolic markers, and socioeconomic status are associated with cognitive function in school-aged children from a population-based cohort.Pediatric research · 2026Article
- The effects of interaction between smoking and abdominal obesity on pre-diabetes mellitus.Scientific reports · 2025Article
- Appetite hormone dysregulation and executive dysfunction among adolescents with bipolar disorder and disruptive mood dysregulation disorder.European child & adolescent psychiatry · 2024Article
- Independent effects of posttraumatic stress disorder diagnosis and metabolic syndrome status on prefrontal cortical thickness and subcortical gray matter volumes.Dialogues in clinical neuroscience · 2023Article
- The interconnection between obesity and executive function in adolescence: The role of the gut microbiome.Neuroscience and biobehavioral reviews · 2023Review
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD.Scientific reports · 2023Article
- Associations between waist circumference and executive function among Chinese Tibetan adolescents living at high altitude.Frontiers in nutrition · 2023Article
- Association Between Sugar-Sweetened Beverage Consumption and Executive Function Among Chinese Tibetan Adolescents at High Altitude.Frontiers in nutrition · 2022Article
- The Prevalence of Diabetes, Prediabetes and Associated Risk Factors in Hangzhou, Zhejiang Province: A Community-Based Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Associations of cardiorespiratory fitness, adiposity, and arterial stiffness with cognition in youth.Physiological reports · 2020Article
- Work-Life Conflict among U.S. Long-Haul Truck Drivers: Influences of Work Organization, Perceived Job Stress, Sleep, and Organizational Support.International journal of environmental research and public health · 2019Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main objective of this study was to investigate the associations between waist circumference, metabolic risk factors, and executive function in adolescents.
methodsThe study was cross-sectional and included 558 adolescents (mean age 14.2 years). Anthropometrics and systolic blood pressure (sysBP) were measured and fasting blood samples were analyzed for metabolic risk factors. A metabolic risk factor cluster score (MetS-cluster score) was computed from the sum of standardized sysBP, triglycerides (TG), inverse high-density lipid cholesterol (HDLc) and insulin resistance (homeostasis model assessment). Cognitive control was measured with a modified flanker task.
resultsRegression analyses indicated that after controlling for demographic variables, HDLc exhibited a negative and TG a positive association with flanker reaction time (RT). Waist circumference did not demonstrate a statistically significant total association with the cognitive outcomes. In structural equation modeling, waist circumference displayed an indirect positive association with incongruent RT through a higher MetS-cluster score and through lower HDLc. The only statistically significant direct association between waist circumference and the cognitive outcomes was for incongruent RT in the model including HDLc as mediator.
conclusionsThese findings are consonant with the previous literature reporting an adverse association between certain metabolic risk factors and cognitive control. Accordingly, these results suggest specificity between metabolic risk factors and cognitive control outcomes. Further, results of the present study, although cross-sectional, provide new evidence that specific metabolic risk factors may mediate an indirect association between adiposity and cognitive control in adolescents, even though a direct association between these variables was not observed. However, taking the cross-sectional study design into consideration, these results should be interpreted with caution and future longitudinal or experimental studies should verify the findings of this study.
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